【職　　稱】 教授（博士生導師） 

【所屬部門】 衛生毒理學系

【電子郵件】 lidchuan@mail.sysu.edu.cn

【研究方向】分子毒理學

【研究生招生專業】衛生毒理學、公共衛生碩士（MPH）

 

【學術簡曆】

       太阳集团1088vip教授/博士生導師，入選國家高層次人才計劃，衛生毒理學系副主任。研究方向為化學緻癌的表觀遺傳調控機制和環境化學物緻癌性風險評估。主持國家自然科學基金3項，廣東省自然科學基金3項，高等學校博士學科點專項科研基金1項，作為骨幹參與國家自然科學基金重點項目，國家重點研發計劃和廣東省自然科學基金研究團隊項目。授權發明專利3項。共發表SCI論著90多篇，包括Environ Health Perspect，Journal of Hazardous Materials，Particle and Fibre Toxicology，Archives of Toxicology，Oncogene，Toxicological Sciences，Environmental pollution，Biochemical Pharmacology，Journal of Biological Chemistry等權威期刊。現任中國毒理學會生化與分子毒理學專業委員會秘書長、中國誘變劑學會緻突變專業委員會青年委員會副主任委員等職務。擔任Toxicol Appl Pharmacol，《癌變·畸變·突變》等國際國内雜志編委。

【教育及工作經曆】 

2025/04-至今         太阳集团app首页               太阳集团1088vip      教授/博導

2019/02-2025/03    太阳集团app首页               太阳集团1088vip      副教授/博導

2016/04-2019/01    太阳集团app首页               太阳集团1088vip      研究員

2014/03-2016/03    美國馬裡蘭大學   藥學院                  博士後

2011/09-2014/02    太阳集团app首页               太阳集团1088vip      講師

2006/09-2011/07    太阳集团app首页               衛生毒理學          博士

2001/09-2006/07    濟甯醫學院           預防醫學系          學士

【社會兼職】

中國毒理學會生化與分子毒理專委會秘書長

中國誘變劑學會緻突變專業委員會青年委員會副主任委員

中華預防醫學會衛生毒理學專業委員會常務委員

中國誘變劑學會生物标志物專委會委員

中華預防醫學會食品衛生分會委員

《癌變·畸變·突變》雜志編委

【承擔課題】

1. 基于人源3D類器官模型的重稀土毒性測試和職業健康風險預警研究 國家自然科學基金專項項目（主持人 2023-2025）

2. 可調控的特定基因甲基化修飾與功能研究細胞模型的建立與應用 國家自然科學基金面上項目（主持人 2019-2022）

3. TRIM36基因高甲基化在多環芳烴誘導肺癌發生過程中的作用及機制研究 國家自然科學基金青年項目（主持人 2017-2019）

4.基于體外消化系統和3D共培養細胞模型建立經口暴露重金屬毒性評價體系 廣東省自然科學基金面上項目（主持人 2021-2023）

5. 臭氧暴露對機體損傷的表觀遺傳時鐘和毒性通路擾動的分子機制 國家自然科學基金重點項目（參與人 2022-2026）

6. 食品中典型持久性有機污染物健康危害與毒性機制 國家重點研發計劃項目（骨幹 2018-2021）

7. 交通源超細顆粒物暴露與神經退行性疾病風險評估的關鍵技術及應用 國家重點研發計劃項目（骨幹 2019-2022）

8. 基于AOP框架構建大氣細顆粒物暴露緻肺癌的風險評估模式 廣東省自然科學基金團隊項目 （骨幹2018-2023）

【代表性論文】（#第一作者，*通訊作者）

1. Rui Zhang, Shen Chen, Ziwei Wang, Lizhu Ye, Yue Jiang, Miao Li, Xinhang Jiang, Hui Peng, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li(*), Wen Chen(*).Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter. Environ Health Perspect. 2023 Jul;131(7):77006.

2. Shuangjian Qin, Huixian Zeng, Qizhen Wu, Qingqing Li, Mohammed Zeeshan, Lizhu Ye, Yue Jiang, Rui Zhang, Xinhang Jiang, Miao Li, Rong Zhang, Wen Chen, Wei-Chun Chou, Guang-Hui Dong, Dao-Chuan Li(*), Xiao-Wen Zeng(*). An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2.5 exposure. Sci Total Environ. 2023 Oct 15:895:165112.

3. Chi Xu, Shuyun Jiang, Xingyu Ma, Zeyong Jiang, Youguang Pan,Xiang Li, Liying Zhang, Hao Zhou, Shen Chen, Xiumei Xing, Liping Chen, Wenfan Fu, Qing Wang, Wen Chen, Daochuan Li(*). CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy. Arch Toxicol. 2023 Feb;97(2):441-456. 

4. Hongxu Bao, Benying Li, Qing You, Xinyu Dun, Zhen Zhang, Yanan Liang, Yahui Li, Qixiao Jiang, Rong Zhang, Rui Chen, Wen Chen, Yuxin Zheng, Daochuan Li(*), Lianhua Cui*. Exposure to real-ambient particulate matter induced vascular hypertrophy through activation of PDGFRβ. J Hazard Mater. 2023 Feb 11;449:130985. 

5. Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li(*), Wen Chen*. Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure. Part Fibre Toxicol. 2022 Jun 23;19(1):42. 

6. Shen Chen(#), Daochuan Li(#), Dianke Yu, Miao Li, Lizhu Ye, Yue Jiang, Shijie Tang, Rui Zhang, Chi Xu, Shuyun Jiang, Ziwei Wang, Michael Aschner, Yuxin Zheng, Liping Chen, Wen Chen. Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers. J Hazard Mater. 2022 Mar 15;426:128089.

7. Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, Michael Aschner, Yuxin Zheng, Lihua Zhang, Wen Chen*, Daochuan Li(*). PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater. 2022 Feb 15;424(Pt C):127624.

8. Zhengbao Zhang, Xiang Li, Shuyun Jiang, Chunfang Qiu, Ping Guo, Ziwei Wang, Chi Xu, Liying Zhang, Xingyu Ma, Shen Chen, Xiumei Xing, Liping Chen, Qing Wang, Huimin Ma, Xiaowen Zeng, Wen Chen, Daochuan Li(*). Assessing the neurotoxicity of airborne nano-scale particulate matter in human iPSC-derived neurons using a transcriptomics benchmark dose model. Toxicol Appl Pharmacol. 2022 Aug 15;449:116109.

9. Zhengbao Zhang(#), Xiumei Xing(#), Shuyun Jiang, Chunfang Qiu, Ziying Mo, Shen Chen, Liping Chen, Qing Wang, Yongmei Xiao, Guanghui Dong, Yuxin Zheng, Wen Chen, Daochuan Li(*). Global H3K79 di-methylation mediates DNA damage response to PAH exposure in Chinese coke oven workers. Environ Pollut. 2021;268(Pt B):115956. 

10. Xiumei Xing(#), Zhini He(#), Ziwei Wang, Ziying Mo, Liping Chen, Boyi Yang, Zhengbao Zhang, Shen Chen, Lizhu Ye, Rui Zhang, Yuxin Zheng, Wen Chen, Daochuan Li(*). Association between H3K36me3 modification and methylation of LINE-1 and MGMT in peripheral blood lymphocytes of PAH-exposed workers. Toxicol Res (Camb). 2020;9(5):661-668.

11. Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang , Huiyao Li , Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiaowen Zeng, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen(*). Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol. 2020; 17(1):22.

12. Shen Chen(#), Daochuan Li(#), Xiaonen Wu(#), Liping Chen, Bin Zhang, Yafei Tan, Dianke Yu, Yong Niu, Huawei Duan, Qiong Li, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen(*). Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environ Int. 2020; 139:105703. 

13. Shen Chen(#), Daochuan Li(#), Haiyan Zhang(#), Dianke Yu, Rui Chen, Bin Zhang, Yafei Tan, Yong Niu, Huawei Duan, Bixian Mai, Shejun Chen, Jianzhen Yu, Tiangang Luan, Liping Chen, Xiumei Xing, Qiong Li, Yongmei Xiao, Guanghui Dong, Yujie Niu, Michael Aschner, Rong Zhang, Yuxin Zheng, Wen Chen(*). The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int. 2019; 131:104943.

14. Daochuan Li, Rong Zhang, Lianhua Cui, Chen Chu, Haiyan Zhang, Hao Sun, Jing Luo, Lixiao Zhou, Liping Chen, Jian Cui, Shen Chen, Bixian Mai, Shejun Chen, Jianzhen Yu, Zongwei Cai, Jianqing Zhang, Yousheng Jiang, Michael Aschner, Rui Chen, Yuxin Zheng, Wen Chen(*). Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environ Pollut. 2019;248:874-887.

15. Liping Chen(#), Ping Guo(#), Haiyan Zhang, Wenxue Li, Chen Gao, Zhenlie Huang, Junling Fan, Yuling Zhang, Xue Li, Xiaoling Liu, Fangping Wang, Shan Wang, Qingye Li, Zhini He, Huiyao Li, Shen Chen, Xiaonen Wu, Lizhu Ye, Qiong Li, Huanwen Tang, Qing Wang, Guanghui Dong, Yongmei Xiao, Wen Chen, and Daochuan Li(*). Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. J Biol Chem. 2019;294(7):2486-2499.

16. Jie Li(#), Xiumei Xing(#), Xinjie Zhang(#), Boxuan Liang, Zhini He, Chen Gao, Shan Wang, Fangping Wang, Haiyan Zhang, Shan Zeng, Junling Fan, Liping Chen, Zhengbao Zhang, Bo Zhang, Caixia Liu, Qing Wang, Weiwei Lin, Guanghui Dong, Huanwen Tang, Wen Chen, Yongmei Xiao, Daochuan Li(*). Enhanced H3K4me3 modifications are involved in the transactivation of DNA damage responsive genes in workers exposed to low-level benzene. Environ Pollut. 2018; 234:127-135.

17. Shan Wang(#), Liping Chen(#), Qing Wang, Zhini He, Shen Chen, Haiyan Zhang, Huiyao Li, Ping Guo, Qiong Li, Rui Zhang, Xiumei Xing, Xiaowen Zeng, Weiwei Lin, Yongmei Xiao, Guang-Hui Dong, Lu Ma, Namratha Gurram, Aihua Zhang, Wen Chen, Daochuan Li(*). Strain differences between CD-1 and C57BL/6 mice in expression of metabolic enzymes and DNA methylation modifications of the primary hepatocytes. Toxicology. 2019;412:19-28.

18. Chen Gao(#), Xiumei Xing(#), Zhini He, Shen Chen, Shan Wang, Qingye Li, Ping Guo, Haiyan Zhang, Huiyao Li, Liping Chen, Qing Wang, Jian Zhao, Yongmei Xiao, Wen Chen(*), Daochuan Li(*). Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization. Gene. 2018; 642:505-512.

19. Huiyao Li(#), Daochuan Li(#), Zhini He, Junling Fan, Qingye Li, Xiaoling Liu, Ping Guo, Haiyan Zhang, Shen Chen, Qiong Li, Rui Zhang, Xiumei Xing, Xiaowen Zeng, Aihua Zhang, Huanwen Tang, Guanghui Dong, Qing Wang, Yongmei Xiao, Liping Chen(*), Wen Chen(*). The Effects of Nrf2 Knockout on Regulation of Benzene-induced Mouse Hematotoxicity. Toxicol Appl Pharmacol. 2018; 358:56-67.

20. Zhini He(#), Daochuan Li(#), Junxiang Ma(#), Liping Chen, Huawei Duan, Bo Zhang, Chen Gao, Jie Li, Xiumei Xing, Jian Zhao, Shan Wang , Fangping Wang, Haiyan Zhang, Huiyao Li, Shen Chen, Xiaowen Zeng, Qing Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen(*). TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollut. 2017; 225:93-103.

21. Xiaonian Zhu(#), Daochuan Li(#), Zhengbao Zhang, Wei Zhu, Wenxue Li, Jian Zhao, Xiumei Xing, Zhini He, Shan Wang, Fangping Wang, Lu Ma, Qing Bai, Xiaowen Zeng, Jie Li, Yongmei Xiao, Qing Wang, Liping Chen, and Wen Chen. Persistent Phosphorylation at Specific H3 Serine Residues Involves in Chemical Carcinogen-induced Cell Transformation. Mol Carcinog. 2017; 56(5):1449-1460.

22. Daochuan Li, Bryan Mackowiak, Timothy G. Brayman, Michael Mitchell, Lei Zhang,Shiew-Mei Huang, Hongbing Wang(*). Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells. Biochem Pharmacol. 2015; 98(1):190-202.

23. Daochuan Li, Caixia Liu Haohui Yu, Xiaowen Zeng, Xiumei Xing, Liping Chen, Chen Gao, Zhengbao Zhang, Yongmei Xiao, Huawei Duan, Yuxin Zheng, Qing Wang, and Wen Chen. AhR Is Negatively Regulated by miR-203 in Response to TCDD or BaP Treatment. Toxicol Res. 2014; 3:142-151.

24. Daochuan Li, Qing Wang, Caixia Liu, Huawei Duan, Xiaowen Zeng, Bo Zhang, Xiaodong Li, Jian Zhao, Shifu Tang, Zhifang Li, Xiumei Xing, Ping Yang, Liping Chen, Junling Zeng, Xiaonian Zhu, Shixin Zhang, Zhengbao Zhang, Lu Ma, Zhini He, Erman Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen. Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene–induced Human Cell Transformation. Toxicol Sci. 2012; 125(2): 382-391.

25. Qing Wang(#), Daochuan Li(#), Zhifang Li, Caixia Liu, Yongmei Xiao, Bo Zhang, Xiaodong Li, Jian Zhao, Liping Chen, Xiumei Xing, Shifu Tang, Yucun Lin, Ping Yang, Junling Zeng, Qin Xiao, Xiaowen Zeng, Zhongning Lin, Zhixiong Zhuang, Shimei Zhuang, Wen Chen(*). Upregulation of miR-27a Contributes to the Malignant Transformation of Human Bronchial Epithelial Cells Induced by SV40 Small T Antigen. Oncogene. 2011; 30(36):3875-86.

26. Liping Chen(#), Yandong Lai(#), Daochuan Li(#), Xiaonian Zhu, Ping Yang, Wenxue Li, Wei Zhu, Jian Zhao, Xiaodong Li, Yongmei Xiao, Y Zhang, Xiumei Xing, Qing Wang, Bo Zhang, Yucun Lin, Junling Zeng, Shixin Zhang, Caixia Liu, Zhifang Li, Xiaowen Zeng, Zongning Lin, Zhixiong Zhuang, Wen Chen(*). α4 is highly expressed in carcinogen- transformed human cells and primary human cancers. Oncogene. 2011; 30(26):2943-53.

【參編著作】

1. 《現代毒理學》，人民衛生出版社，2018年

2. 《基于毒作用模式的典型食品污染物風險評估》，太阳集团app首页出版社，2021年

招生專業
　　衛生毒理學