A. Research Interest
Inflammatory diseases including atherosclerotic cardiovascular diseases are the leading cause of death worldwide. Diet, one type of lifestyles, regulates the pathogenesis of inflammatory diseases. Inflammatory diseases are often delayed in populations consuming plant food-based diet compared to those receiving animal food-based diet. However, the effects and mechanisms for inflammatory disease protective effects of plant foods are not yet well established. Using preclinical trials our group have investigated the impact of chicory, one typical leafy vegetable in the Mediterranean Diet on inflammatory diseases, and observed that chicory could inhibit atherosclerosis development likely through its bioactive components protocatechuic acid and lactucopicrin. Currently, together with clinical and preclinical trials, we are evaluating the effects of chicory and its bioactive components on the risk or severity of atherosclerosis as well as inflammatory bowel diseases.
B. Grant Awards (PI)
National Natural Science Foundation of China .No.82273617; 81973014;81573141; 81202196.
C. Selected Publication
1.Qing Li, Xiuping Liu, Yushi Du, Xu Zhang, Panyin Xiang, Guanyu Chen, Wenhua Ling, Dongliang Wang.Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK. Science Signaling. 2023.16(786):eabn1372.(原兒茶酸提高巨噬細胞吞噬凋亡細胞的能力)
2.Dongliang Wang, Min Xia, Xiao Yan, Dan Li, Lei Wang, Yuxuan Xu, Tianru Jin and Wenhua Ling. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b. Circulation Research. 2012.111(8): 967-981. (花色苷腸道菌代謝物原兒茶酸促進巨噬細胞膽固醇外流）
3.Dongliang Wang, Wenting Wang, Weiqun Lin, Wenqi Yang, Peiwen Zhang, Ming Chen, Ding Ding, Chaoqun Liu, Jiakun Zheng, Wenhua Ling. Apoptotic cell induction of miR-10b in macrophages contributes to advanced atherosclerosis progression in ApoE-/- mice. Cardiovascular Research. 2018.114(13):1794-1805. (原兒茶酸感受器miR-10b是防控動脈粥樣硬化的潛在新靶點）
4.Zheng Jiakun, Li Qing, He Luanying, Weng Hui, Su Dongfang, Liu Xiuping, Ling Wenhua, Wang Dongliang. Protocatechuic acid inhibits vulnerable atherosclerotic lesion progression in older apoe-/- mice. Journal of Nutrition, 2020.150(5):1167-1177.(原兒茶酸提高晚期動脈粥樣硬化斑塊穩定性）
5. Qing Li, Xu Zhang, Yushi Du, Xiuping Liu, Guanyu Chen, Panying Xiang, Hao Wu, Chaoqun Liu, Dongliang Wang. Brussels chicory stabilizes unstable atherosclerotic plaques and reshapes the gut microbiota in Apoe-/- mice. Journal of Nutrition, 2022.152:2209–2217(富含原兒茶酸和山莴苣苦素的藥食兩用食物菊苣提高晚期動脈粥樣硬化斑塊穩定性）
D. Academic Awards
1.2021 The First Award of National Science Award of The Ministry of Eduction（No.2020-049-R03）
2.2024 The First Award of National College Student Health Science Polularization Competition as a Supervisor
