學術簡曆

1. 教育背景
1992-1997  本科  哈爾濱醫科大學預防醫學系   
1997-2000  碩士  中山醫科大學營養系
2002-2006  博士  美國Case Western Reserve University School of Medicine           
                （凱斯西儲大學）營養系
    
2.工作經曆
2000-2002   講師               中山醫科大學太阳集团1088vip；
2006-2009   博士後           美國克利夫蘭臨床中心；            
2010-2011   博士後/講師   美國西奈山醫學中心；
2011-2013     講師             美國康奈爾大學醫學院；
2013.04至今   教授            太阳集团1088vip

社會兼職

廣東省腦卒中與預防康複學會常務理事；廣東省營養學會理事；美國色譜質譜學會會員；美國自由基醫學會會員；擔任J of Hepatology; Liver International; Fundamental & Clinical Pharmacology; Free Radical Biology & Medicine; J of Nutrition; Nutrition Research; Alcohol; Alcohol and Alcoholism等期刊的審稿人。

主要承擔或參與的課題

1. 國家自然科學基金面上項目，2019/01-2022/12，課題負責人；
2. 國家自然科學基金面上項目，2016/01-2019/12，課題負責人；
3. 國家自然科學基金面上項目，2014/01-2017/12，課題負責人；
4. 廣東省特支計劃青年拔尖人才資助計劃，2017/10-2020/10，課題負責人;
5. 廣東省自然科學基金面上項目，2015/09-2017/12，課題負責人；
6. 廣東省科技廳協同創新重大項目，2016/09-2018/09，主要參與人;
7. 教育部回國人員啟動基金， 2015/03-2016/03，課題負責人；
8. 太阳集团app首页重大培育項目， 2016/01-2017/12，課題負責人
9. 太阳集团app首页百人計劃引進人才項目， 2013-2015，課題負責人

近期發表的主要文章 (* 通訊作者)

1．Wang, S., Wan, T., Ye, M., Qiu, Y., Pei, L., Jiang, R., Pang, N., Huang, Y., Liang, B., Ling, W., Lin, X*., Zhang, Z*., Yang, L*. Nicotinamide Riboside Attenuates Alcohol induced Liver Injuries via Activation of SirT1/PGC-1α/Mitochondrial Biosynthesis Pathway. Redox Biol. 2018. https:// doi.org/10.1016/j.redox. 2018. 04. 006. 
2．Pei, L., Wan,T., Wang, S., Ye, M., Qiu, Y., Jiang,R., Pang, N., Huang, Y., Zhou, Y., Jiang,X., Ling, W., Zhang,Z., Yang,L.*. Cyanidin-3-O-β-glucoside regulates the activation and the secretion of adipokines from brown adipose tissue and alleviates diet induced fatty liver. Biomedicine & Pharmacotherapy. 2018, in press. 
3． Qiu, Y., Wang, S., Wan, T., Ye, M., Jiang, R., Pei, L., Yang, L*. Blod-based novel biomarkers for nonalcoholic steatohepatitis. Biomarkers in Medicine. 2018. In press. 
4.  Qiu, Y., Wang, S., Yu, C., Chen, Q., Jiang, R., Pei, L., Huang, Y., Pang, N., Zhang, Z*., Ling, W*., Yang, L*. Association of Circulating Adipsin, Visfatin and Adiponectin with Nonalcoholic Fatty Liver Disease in Adults: A Case-Control Study. Annals of Nutrition and Metabolism. 2018. In press.  
5.  Ye，M., Wan, T., Pang, N., Wei, T., Huang, Y., Jiang, X., Zhang, Z* , Yang, L*., Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis. J of Cancer. 2018. In press. 
6.  Wan，T., Wang，S., Ye,M., .Ling, W. and Yang, L*. Cyanidin-3-O-β-glucoside protects against liver fibrosis induced by alcohol via regulating energy homeostasis and AMPK/autophagy signaling pathway. J of Funct. Food. 2017；37：16-24. 
7.  Chen, M., Liu, J., Yang, L*., Ling, W*.  AMP-activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepaticstellate cells through inhibition of autophagy. FEBS Open Bio. 2017；7：811-820. 
8.  Yang, LP., Ling, W., Du, Z., Chen, Y., Li, D., Deng, S., Liu,Z*., Yang, L*. Effects of anthocyanins on cardiometabolic health: a systematic reviewand meta-analysis of randomized controlled trials. Advances in Nutrition. 2017：8(5)；684-693. 
9 . Ye, M., Wang, S., Wan,T., Jiang,R.,Qiu, Y., Pei, L., Pang,N., Huang, Y., Huang, Y., Zhang, Z*., Yang, L*.  Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer. J of Cancer. 2017 ；8：3774-3784. 
10.  Yang， LP., Ling, W., Yang, Y., Chen, Y., Tian, Z., Du, Z., Chen, J., Xie, Y., Liu, Z*., Yang, L*. Role of putified anthocyanins in improving cardiometabolic risk factors in Chineses Men and Women with prediabetes or early untreated diabetes- a randomized controlled trial. Nutrients. 2017;9:1104-1118.
11.  Yang, L*., Rozenfeld R., Wu, D., Devi, LA., Zhang, Z.*, and Cederbaum A*. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radical Biology & Medicine. 68: 260-267, 2014. 
12.  Yang, L., Wu, D., and Cederbaum, AI*. CYP2E1, oxidative stress and MAPK signaling pathway in alcohol-induced hepatotoxicyt. (Review). J of Biochem and Pharm Res.2(2):74-90, 2014 .
13．Yang, L.*, Wu, D., Wang, X., and Cederbaum, AI*. Interactions between CYP2E1, JNK, Autophagy and oxidative stress in acute alcohol-induced fatty liver. Free Radical Biology & Medicine. 53; 1170-1180, 2012. 
14．Yang, L*., and Cederbaum, AI. Interaction of CYP2E1 and anti-oxidative stress factors in alcoholic liver disease. Recent Advances in Alcoholic Liver Disease, 27-45 ISBN: 978-81-7895-571-1, 2012.
15．Yang, L., Wu, D., Wand, X., and Cederbaum, AI*.. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1 induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radical Biology & Medicine. 2011; 51: 185-196.
16. Yang, L., and Cederbaum, AI*.. CYP2E1, oxidative stress and MAPK signaling pathway in alcoholic liver disease (review). Research Trends- Current Topics in Toxicology. 2011(7): 1-11.
17. Yang, L., Latchoumycandane, C, McMulllen, M.R., Pratt, B.T., Zhang, R., Papouchado, B.G., Nagy, L.E., Feldstein, A.E., and McIntyre TM*.. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J. Biol. Chem. 2010; 285(29):22211-20.
18．Yang L., Kombu RS, Kasumov T, Zhu SH, Cendrouski AV, David F, Anderson VE, Kelleher JK, Brunengraber H. Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: I. Interrelation between gluconeogenesis and catapleorosis: Formation of methoxamates from aminooxyacetate and ketoacids. J. Biol. Chem. 2008; 283(32): 21978-21987. 
19．Yang L., Kasumov T, Kombu RS, Zhu SH, Cendrouski AV, David F, Anderson VE, Kelleher JK, Brunengraber H. Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern. J. Biol. Chem. 2008; 283(32): 21988-21996. 
20. Yang L., Kasumov T, Lynn Yu, Jobbins KA, David F, Kelleher JK, Previs SF, Joanne, K. Kelleher and Brunengraber H. Metabolomic assays of the concentration and mass isotopomer distributions of gluconeogenic and citric acid cycle intermediates. Metabolomics. 2006; 2(2): 85-94. 
21. Ismailoglu, I., Chen, Q., Popowski, M., Yang, L., Gross, S.S. *, and Brivanlou, AH*. Huntingtin protein is essential for mitochondrial metabolism bioenergetics and structure in murine embryonic stem cells. Developmental Biology. 2014; 391: 230-240.
22．Wang, X., Wu D., Yang, L., Gan, L., Cederbaum, AI*.  CYP2E1 Potentiates     Ethanol-induction of Hypoxia and HIF-1α in vivo. Free Radical Biology & Medicine. 63:175-186, 2013.
23．Wu, D., Wang, X., Yang, L., and Cederbaum, AI*. Role of Autophagy in the Modulation of Cytochrome P4502E1-mediated Binge Alcohol Liver Steatosis and Cytotoxicity. Free Radical Biology & Medicine. 53(6): 1346-57, 2012.
24．Cederbaum, AI*, Yang, L., Wang, X, Wu, D. CYP2E1 sensitizes the liver to LPS and TNF-induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen activated kiniases. International J of Hepatology. 2012; 2012: 582790.
25. Wang, X., Wu, D., Yang, L., Cederbaum, AI*. Hepatotoxicity mediated induced by TNFα was mediated by JNK1 but not JNK2. Hepatology. 2011. 54(5):1753-66.
26. Chen J., Yang L., Foulks JM, Weyrich AS, Marathe GK, McIntyre TM. Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. J Lipid Res. 2007; 48(11):2365-76.
27．Chen R., Yang L., and McIntyre TM. Cytotoxic phospholipid oxidation products: cell death from mitochondrial damage and the intrinsic caspase cascade. J. Biol. Chem. 2007; 282(34):24842-50.
28．王素凡，楊麗麗*.酒精性肝病的機制及研究進展. 國際肝病. 2013; 10-12-13.
29．萬婷，楊麗麗*. 花色苷對酒精性肝病的防治及機制. 華南預防醫學. 2017；43（2）： 187-191.
30．楊麗麗，淩文華，馬靜，唐志紅，吳聰娥。溶血卵磷脂對巨噬泡沫細胞膽固醇外流的影響。中國病理生理雜志， 2001; 18 (1): 28-31.
31．楊麗麗, 淩文華, 馬靜, 唐志紅。鈣離子信使通路在溶血卵磷脂促進巨噬泡沫細胞膽固醇。中國動脈硬化雜志，2001; 9 (3): 190-193.
32．楊麗麗，淩文華。氧化型低密度脂蛋白與動脈粥樣硬化（綜述）。國外醫學内科學分冊，2000; 27 (2): 58-61。
33. 丘雲，王素凡，裴蕾，姜瑞，楊麗麗. 廣州市成年人非酒精性脂肪肝的相關因素。熱帶醫學雜志，2018,18（3）:279-284.
34. 姜瑞，王素凡，丘雲，裴蕾，楊麗麗. 尼克酰胺核糖對C57BL/6J小鼠糖耐量、胰島素抵抗的影響及其機制研究。熱帶醫學雜志，2018（4）:18-22.
35. 裴蕾，萬婷，王素凡，楊麗麗. 桑葚花色苷提取物對高脂酒精膳食作用下小鼠棕色脂肪組織改變的影響。熱帶醫學雜志，2018(5)
 
參編書籍： 
《Basic Nutrition and Diet Therapy》 編者
《腫瘤營養學》編者
《公共衛生學概論》編者
《中國公共衛生理論與實踐》編者

研究生培養情況

現培養博士生1名，碩士生5名。
已經培養博士生2名，碩士生6名，MPH碩士2名, 本科生5名。

獲獎情況

廣東省特支計劃青年拔尖人才
太阳集团app首页百人計劃引進人才
太阳集团1088vip青年教師英文授課大賽第一名
太阳集团app首页青年教師英文授課大賽三等獎
連續兩次指導太阳集团1088vipMPH 碩士優秀論文

招生專業

營養與食品衛生學

招生/招聘信息

招收博士後、專職科研人員、副研究員；
招收博士生、碩士生、本科生；
歡迎對代謝性疾病、脂肪肝、肝纖維化發病機制，以及相關營養防治的人群與實驗室研究、腸道菌群、及生物标志物探讨感興趣的本科生、碩士生、博士生、博士後及專職科研人員加入我們的大家庭。