學術簡曆

[學術經曆]
2002.09～2007.06     太阳集团1088vip        博士學位
1997.09～2002.06     中山醫科大學太阳集团1088vip    學士學位
[工作經曆]

2021.07~至今           太阳集团app首页太阳集团1088vip  副院長

2019.01~2021.07     太阳集团app首页教務部  副處長

2019.01~至今           太阳集团1088vip衛生毒理系  副主任

2015.09~2018.12     預防醫學系  黨支部書記

2013.01~2015.01     美國斯坦福大學臨床科研中心基因研究所  訪問學者
2018.04~至今           太阳集团1088vip衛生毒理系        教授
2011.01~2018.04     太阳集团1088vip預防醫學系        副教授
2007.07~2010.12     太阳集团1088vip預防醫學系        講師

 
社會兼職

  • 中國環境誘變劑學會-環境表觀遺傳學專業委員會 主任委員 2023-2027

  • 廣東省醫師協會公共衛生醫師分會 副理事長 2023-2027

  • 廣東省毒理學學會 副理事長 2024-2029

  • 《中國公共衛生》雜志 第七屆編輯委員會青年編委 2017-2021

  • 《癌變.畸變.突變》雜志第七屆編輯委員會編委 2017-2021



主持的科研項目：

  • 國家自然科學基金面上項目，82373546，基于人源類器官模型的锂電池産業金屬混合暴露腎髒毒性檢測及職業健康風險評估研究 2024.01-2027.12

  • 國家自然科學基金面上項目，82073583，基于單細胞測序技術探讨聚苯乙烯微塑料誘導肝髒脂質代謝異常的作用機制，2021.01-2024.12

  • 國家重點研發計劃， SQ2019YFC1604603，食品中重金屬污染物去除技術及安全性評價，2019.12-2022.12

  • 國家自然科學基金面上項目，81673140，長鍊非編碼RNA在調控二甲基甲酰胺誘導肝髒毒性中的作用及其機制，2017.1-2020.12

  • 國家自然科學基金面上項目，81273098，微小RNA在化學緻癌物生物轉化中的功能，2013.01-2016.12 

  • 國家自然科學青年基金項目，30800930，miRNA在化學緻癌過程中的功能性研究，2009.01-2011.12

  • 廣東省自然科學基金面上項目，2024A1515012268，基于AOP網絡和類器官模型開展重金屬混合暴露肝毒性風險評估研究 2024.01-2026.12

  • 廣東省自然科學基金面上項目，2019A1515011457，miR-192-5p在二甲基甲酰胺誘導職業性肝損傷中的作用機制，2019.10-2022.09



近期發表的主要文章

  • Zhihan Zhang, Mengxing Cui, Han Wang, Wenke Yuan, Ziqi Liu, Huan Gao, Xinchao Guan, Xiaoyu Chen, Lijie Xie, Shilin Chen, Yujie He, Qing Wang*. Co-exposure to F-53B and nanoplastics induced hepatic glucolipid metabolism disorders by the PI3K-AKT signaling pathway. Environmental Pollution. 2025; 368: 125771.
  • Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang*. Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set enrichment analysis. Ecotoxicology and Environmental Safety. 2025. 290: 117740.
  • Ziqi Liu, Huan Gao, Guoliang Li,Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu*, Qing Wang*. Genome-wide CRISPR-based Screen Identifies E2F transcription factor 1 as a Regulator and Therapeutic Target of Aristolochic Acid-induced Nephrotoxicity. Environment International. 2024. 195:109234.
  • Lijie Xie, Xinchao Guan, Yixiang Zhou, Yujie He, Shilin Chen, Wanting Xiao, Jilong Yang, Jianyong Lu, Liecheng Hong, Qiansheng Hu, Qiong Wang, Chuanwen Li* and Qing Wang*. Exploring Associations and Mediating Factors between Multiple Trace Metals with Anemia in US Adults: Insight from NHANES 2017-2020. Nutrients. 2024. 16, 3424.
  • Xue Zhang, Huan Gao, Xiaoyu Chen, Ziqi Liu, Han Wang, Mengxing Cui, Yajie Li, Yongjiang Yu, Shen Chen, Xiumei Xing, Liping Chen, Daochuan Li, Xiaowen Zeng, Qing Wang*. Identification of Sanguinarine as a novel antagonist for Perfluorooctanoate/Perfluorooctane Sulfonate-induced Senescence of Hepatocytes: An integrated computational and experimental analysis. Journal of Hazardous Materials. 2024. 478:135583
  • Han Wang, Dongtian Miao, Yongjiang Yu, Zhihan Zhang, Youlong Zhu, Qing Wang*. PVA/PAA/DMTD electrospun nanofibrous membrane for the selective adsorption of Pb(II) ions in liquid foods. iScience. 2023, 108737.
  • Peng H, Fu W, Chang C, Gao H, He Q, Liu Z, Cui M, Wang H, Yu Y, Wu Y, Zhang X, Jiang S, Xu C, Shen X, Zhang Z, Zhou Y, Li D*, Wang Q*. The transcription activity of OTX2 on p16 expression is significantly blocked by methylation of CpG shore in non-promoter of lung cancer cell lines. Transl Cancer Res. 2023;12(10):2582-2595.
  • Zhai D, Zhou Y, Kuang X, Shao F, Zhen T, Lin Y, Wang Q*, Shao N*. Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis. Int J Med Sci. 2023;20(9):1152-1162.

  • Mengxing Cui, Qianmei He, Ziwei Wang, Yongjiang Yu, Huan Gao, Ziqi Liu, Honghao Peng, Han Wang, Xue Zhang, Daochuan Li, Liping Chen, Xiumei Xing, Yongmei Xiao, Wen Chen, Qing Wang*. Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity. Environmental Pollution. 2023: 121808.

  • Yangchun Zhang, Ziqi Liu, Ziwei Wang, Huan Gao, Yuqing Wang, Mengxing Cui, Honghao Peng, Yongmei Xiao, Yuan Jin, Dianke Yu, Wen Chen and Qing Wang* Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests. Journal of Hazardous Materials.2023. 443(Pt A):130191.

  • Fei Wu, Yangchun Zhang, Xu Chen, Yuqing Wang, Honghao Peng, Zhengbao Zhang, Ying Yang*, Qing Wang*. Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression. Environmental Science and Pollution Research. 2022；29(8):11883-11892

  • Yong-Wei Xiong, Yu-Jie Feng, Tian Wei, Xiang Zhang, Lu-Lu Tan, Jin Zhang, Li-Min Dai, Hua-Long Zhua, Guo-Xiang Zhou, Wei-Bo Liu, Zi-Qi Liu, Xiao-Feng Xu, Lan Gao, Cheng Zhang, Qing Wang*, De-Xiang Xu*, Hua Wang*. miR-6769b-5p targets CCND-1 to regulate proliferation in cadmium-treated placental trophoblasts: Association with the impairment of fetal growth. Ecotoxicology and Environmental Safety. 2021；230：113109
  • Xu Chen, Yi Tang, Shen Chen, Wen-Hua Ling, and Qing Wang*. IGFBP-2 as a biomarker in NAFLD improves hepatic steatosis:an integrated bioinformatics and experimental study. Endocrine Connections. 2021
  • Ye Liu, Cuiju Wen, Yangchun Zhang, Ziqi Liu, Qianmei He, Mengxing Cui, Honghao Peng, Yuqing Wang, Xueying Zhang, Xudong Li, Qing Wang*. Aberrant expression of SNHG12 contributes to N, N-dimethylformamide-induced hepatic apoptosis both in short-term and long-term DMF exposure. Toxicology Research. 2021
  • Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu and Qing Wang* Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach. Frontiers in Genetics. 2021
  • Ziqi Liu, Qianmei He, Ye Liu, Yangchun Zhang, Mengxing Cui, Honghao Peng, Yuqing Wang, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Qing Wang*. Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis. Toxicology. 2021; 458:152838.
  • Zhuo-Zhi Liang, Rui-Mei Zhu, Yue-Lin Li, Hong-Mei Jiang, Ruo-Bi Li, Lu-Ying Tang, Qing Wang*, Ze-Fang Ren*. Differential epigenetic and transcriptional profile in MCF-7 breast cancer cells exposed to cadmium. Chemosphere. 2020; 261:128148

  • Zhen Zhang, Wei Zhu, Ziqi Liua, Ye Liu, Chong Chang, Hongmei Jiang, Ruobi Li, Yongmei Xiao, Wen Chen, Qiansheng Hu*, Qing Wang*. Aberrant expression of miRNA-192-5p contributes to N,N-Dimethylformamide-induced hepatic apoptosis. J Appl Toxicol. 2020; 40 (12), 1683-1693

  • Hongmei Jiang, Ruobi Li, Zhen Zhang, Chong Chang, Ye Liu, Ziqi Liu, Qianmei He, and Qing Wang*. Retinoid X receptor α (RXRα)-mediated erythroid-2-related factor-2 (NRF2) inactivation contributes to N,Ndimethylformamide (DMF)-induced oxidative stress in HL-7702 and HuH6 cells. J Appl Toxicol. 2020; 40(4):470-482

  • Zeng N#, Zhang Z#, Jiang H, Li R, Chang C, Wang F, Xu D, Fan Q, Wang T, Xiao Y, Chen W, Shan Z, Huang Z, Wang Q*. LncRNA-241 inhibits 1,2-Dichloroethane-induced hepatic apoptosis. Toxicol In Vitro. 2019; 61:104650.

  • Liu Z, Cai L, Liu Y, Chen W, Wang Q*. Association between prenatal cadmium exposure and cognitive development of offspring: A systematic review. Environ Pollut. 2019; 254(Pt B):113081.

  • Wang F#, Chang C#, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q*. Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology. 2019; 424:152236

  • Ni Zeng, Rong Huang, Nan Li, Hongmei Jiang, Ruobi Li, Fei Wang, Wen Chen, Min Xia, Qing Wang*. MiR-451a attenuates free fatty acids–mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. Mol Cell Endocrinol. 2018; 474:260-271

  • Fei Wang, Tao Guo, Hongmei Jiang, Ruobi Li, Ting Wang, Ni Zeng, Guanghui Dong, Xiaowen Zeng, Daochuan Li, Yongmei Xiao, Qiansheng Hu, Wen Chen, Xiumei Xing* and Qing Wang*. A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines. Molecular Genetics and Genomics. 2018; 293(3):769-783

  • Zeng Ni, Jiang Hongmei, Fan Qiming, Wang Ting, Rong Weifeng, Li Guoliang, Li Ruobi, Xu Dandan, Guo Tao, Wang Fei, Zeng Lihai, Huang Manqi, Zheng Jiewei, Lu Fengrong, Chen Wen, Hu Qiansheng, Huang Zhenglie*, Wang Qing*.  Aberrant expression of miR-451a contributes to 1,2-dichloroethane-induced hepatic glycerol gluconeogenesis disorder by inhibiting glycerol kinase expression in NIH Swiss mice. J Appl Toxicol. 2018; 38(2):292-303

獲獎情況

  • 2009年 參與完成的“動脈粥樣硬化的病理機制以及花色苷防治研究”獲得廣東省科學技術一等獎

  • 2010年 參與完成的“動脈粥樣硬化的病理機制以及花色苷防治研究”獲得教育部自然科學獎一等獎

  • 2010年 參與完成的“動脈粥樣硬化的病理機制以及花色苷防治研究”獲得中華醫學科技獎二等獎 

  • 2016年“膳食多酚類活性物質防治代謝性疾病的基礎及應用研究” 中華醫學科技獎二等獎

  • 2017年“膳食多酚類活性物質防治代謝性疾病的基礎及應用研究” 廣東省科技獎二等獎

  • 2017年 第二屆“廣東省中青年教師公共衛生與預防醫學本科課程教學競賽” 一等獎

實驗室簡介
　　實驗室的主要研究方向是環境健康以及食品安全的風險評估，着重于計算毒理學與分子毒理學的融合性研究。實驗室通過多種技術手段（包括機器學習，高通量測序技術，生物信息學，分子細胞生物學等），以人、小鼠、體外細胞為研究對象，揭示環境與食品中有害物質的風險性。

博士後/特聘副研究員招聘
　　實驗室常年招聘衛生毒理/職業衛生/食品安全方向的博士後或者特聘副研究員。要求為已獲得相關專業博士學位，以及有獨立從事課題研究的能力，具有強烈的研究興趣，良好的合作與團隊精神。合同為年薪制，年薪30至50萬。

研究生招生
實驗室歡迎熱愛以上相關研究的優秀學生來了解碩士和博士研究生招生計劃。