學術簡曆
1984.9-1990.7上海醫科大學 預防醫學系預防醫學專業本科,獲醫學學士學位
1996.9-1998.7中山醫科大學 勞動衛生職業病與衛生毒理學專業碩士研究生
1998.9-2001.7中山醫科大學 衛生毒理學專業博士研究生,獲醫學博士學位
2001.7-2004.4中山(醫科)大學 講師
2004.5-2006.9 太阳集团app首页 副教授/碩士導師
2004.12-2006.12 美國耶魯大學 博士後
2007.1-2011.12美國耶魯大學 助理研究員
2011.12- 太阳集团app首页“百人計劃”引進人才 教授/博士生導師
社會兼職
★國家級和省級專業學會任職:
1)中國毒理學會理事;
2)中國環境誘變劑學會理事;
3)中國毒理學會遺傳毒理學專業委員會副主任委員
4)廣東省毒理學會常務理事;
5)廣東省環境誘變劑學會理事;
6)廣東省預防醫學會毒理學專業委員會委員
★國家醫學考試中心專家委員會專家
★國家級和省級雜志擔任編委:
1)《中華預防醫學雜志》編委;
2)《癌變畸變突變》雜志編委;
3)《環境與職業醫學》雜志編委;
4)《中國職業醫學》雜志編委;
5)《華南預防醫學雜志》編委;
6)《環境科學學報》編委。
★SCI雜志審稿人
1)environmental toxicology and pharmacology
2)Chinese Journal of Cancer
主要承擔或參與的課題
1. 心血管發育毒性相關基因和毒物篩查及毒性通路研究 國家自然科學基金(編号81472998) 2015.1-2018.12(主持人、在研)
2. CCM3基因缺陷小鼠鉛暴露模型及人群遺傳易感性研究 國家自然科學基金(編号81273097) 2013.1-2016.12(主持人、在研)
3. 具有心血管毒性的環境化學污染物的篩查 太阳集团app首页“百人計劃”引進人才科研啟動基金項目 2012.1-2014.1(主持人、在研)
4. DNA修複酶MSH2缺陷對苯代謝産物遺傳毒性的影響 國家自然科學基金(編号30200230)(主持人)2003.1~2005.12
5. DNA修複酶MSH2缺陷與腫瘤發生的關系 廣東省自然科學基金(編号021816)(主持人)2003.1~2005.12
6.環境化學污染物(ECPs)緻DNA損傷及其修複與遺傳通路的研究 國家重點基礎研究發展規劃項目(973計劃)子項目(編号:2002CB512903)(第二負責人)2003.1~2007.12
近期發表的主要文章
1. Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W, He Y*. Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3. Toxicol Lett. 2016, 254: 22-31. (*通訊作者)
2. Ji W, Li Y, He Y*, Yin M, Zhou HJ, Boggon TJ, Zhang H, and Min W. AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis. Cancer Res, 2015, 75(17):3492-504. (*共同第一)
3. He Y*, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W. Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Science Signaling,2010;3(116):ra26. (《科學雜志》子刊)(*第一作者)
4. He Y*, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin. Invest, 2006;116(9):2344-2455. (*第一作者)
5. He Y*, Zhang W, Zhang R, Zhang H, and Min W. SOCS1 Inhibits Tumor Necrosis Factor-induced Activation of ASK1-JNK Inflammatory Signaling by Mediating ASK1 Degradation. J Biol Chem,2006;2819(9):5559-5566. (*第一作者)
6. Zhang H, He Y*, Dai S, Xu Z, Luo Y, Wan T, Luo D, Jones D, Tang S, Chen H, Sessa WC, Min W. AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest,2008;118(12):3904-16. (*共同第一)
7. Qi D, Hu Y, Li J, Peng T, Su J, He Y*, Ji W. Hyperthermia Induces Apoptosis of 786-O Cells through Suppressing Ku80 Expression. PLoS One,2015;10(4):e0122977. (*共同通訊)
8. Dai S, He Y*, Zhang H, Yu L, Wan T, Xu Z, Jones D, Chen H, Min W. Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis. Arterioscler Thromb Vasc Biol, 2009;29(4):495-502. (*共同第一)
9. Luo D, LuoY, He Y*, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W.. (2006) .Differential functions of TNFR1 and TNFR2 signaling in ischemia -mediated arteriogenesis and angiogenesis. Am J Pathol, 2006;169(5):1886-1898. (*共同第一)
10. Zhang H, Zhang W, Luo Y, He Y, Zhang R, Min W, et al. Endothelial-Specific Expression of Mitochondrial Thioredoxin Improves Endothelial Cell Function and Reduces Atherosclerotic Lesions. Am J Pathol,2007;170:1108-1120 (*共同第一)
11. Luo D, He Y, Zhang H, Yu L, Chen H, Xu Z, Tang S, Urano F, Min W. AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem,2008;283(18):11905-12.
12. Yu L, Min W, He Y, Qin L, Zhang H, Bennett AM, Chen H. JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. J Biol Chem,2009;284(20):13481-8.
13. Li X, Zhang R, Zhang H, He Y, Ji W, Min W, Boggon TJ. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. J Biol Chem,2010;285(31):24099-107.
14. Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng EC, Chen H, Krause DS, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med,2010;207(6):1183-95.
15. Luo Y, Xu Z, Wan T, He Y, Zhang H, Min W. Endothelial-Specific Transgenesis of TNFR2 Promotes Adaptive Arteriogenesis and Angiogenesis. Arterioscler Thromb Vasc Biol,2010;30(7):1307-14.
16. Li X, Luo Y, Yu L, Lin Y, Luo D, Zhang H, He Y, Kim YO, Kim Y, Tang S, Min W. SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ,2008;15(4):739-50.
17. Yu L, Qin L, Zhang H, He Y, Chen H, Pober JS, Tellides G, Min W. AIP1 prevents graft arteriosclerosis by inhibiting interferon-γ-dependent smooth muscle cell proliferation and intimal expansion. Circ Res,2011;109(4):418-27.
18. Jones D, Xu Z, Zhang H, He Y, Kluger MS, Chen H, Min W. Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis. Arterioscler Thromb Vasc Biol,2010;30(12):2553-61.
19. Min W, Xu LK, Zhou HJ, Huang Q, Zhang H, He Y, Zhe X, Luo Y. Thioredoxin and redox signaling in vasculature-studies using Trx2 endothelium-specific transgenic mice. Methods Enzymol,2010;474:315-24.
20. Fang DK, He Y, Zhang JQ, Hu DL, Sha Y, Zhuang ZX. X-ray repair cross complementing group 1 protects human bronchial epithelial cells from hydroquinone-induced DNA damage. Chinese Journal of Pharmacology and Toxicology,2009;23(2):89-98.
21. Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z,Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012 Jul 15;72(14):3512-21.
22. Jones D, Li Y, He Y, Xu Z, Chen H, Min W. Mirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):633-42.
研究生培養情況
博士生:4名
科研型碩士:12名
公共衛生碩士:6名
招生專業
衛生毒理學
獲獎情況
(1)獲得第三屆亞洲毒理學會國際會議“Outstanding Achievement Young Scientist Presentation Award”;
(2)獲得第五屆耶魯大學“Vascular Biology&Transplantation Retreat Best Poster Prize”;
(3)獲得第六屆耶魯大學“Vascular Biology&Transplantation Retreat Best Poster Prize”;
(4)入選太阳集团app首页“百人計劃”