【職　　稱】 教授（博士生導師） 

【所屬部門】 衛生毒理學系

【電子郵件】 chenwen@mail.sysu.edu.cn

【研究方向】（主要研究領域）

分子與遺傳毒理學
 

【學術簡曆】

　　2005年作為人才引進受聘于太阳集团1088vip，長期緻力于遺傳毒理學和環境化學緻癌機理方面的研究。獲得國家傑出青年基金（2009年）；主持國家自然科學基金重點項目4項；主持國家重點研發計劃項目（課題負責人）；參與國家重點基礎研究計劃(973)項目、863重大項目、衛生部公益項目、科技部支撐計劃項目等課題的研究。入選“珠江學者”特聘教授；獲中國毒理學傑出貢獻獎，《毒理學基礎》教材副主編。在國内外雜志發表論文300餘篇，其中SCI收錄文章100+篇。主要研究方向是：人體細胞轉化模型建立和應用；環境緻癌表觀遺傳機制以及人群生物标記物研究；DNA損傷修複以及氧化損傷的表觀遺傳調控機制。

【社會兼職】

1. 中國毒理學會副理事長
2. 中國環境誘變劑學會副理事長
3. 《Food Chem Toxicol 》共同主編
4.《Environ Pollut 》副主編
5.《中華預防醫學雜志》副總編
6. 環保部化學物質環境管理評審專家

【主要承擔的課題】

1. 臭氧暴露對機體損傷的表觀遺傳時鐘和毒性通路擾動的分子機制 國家自然科學基金重點項目 （課題主持人 2022-2026, 82130094）
2. 大氣細顆粒物健康危害的系統毒理學與系統流行病學研究 國家自然科學基金重大研究計劃集成項目（課題組成員 2020-2022, 91943301）
3. 交通源超細顆粒物暴露與神經退行性疾病風險評估的關鍵技術及應用 國家重點研發計劃 (骨幹 2019.7.1-2022.6.30)
4. 食品典型污染物低劑量暴露的毒作用模式研究 國家重點研發計劃（課題主持人 2018-2021）
5. 基于AOP框架構建大氣細顆粒物暴露緻肺癌的風險評估模式 廣東省團隊項目（課題主持人 2018-2023）
6. 基于毒性通路的大氣細顆粒物暴露緻肺癌機制研究國家自然科學基金重大研究計劃重點項目（課題主持人 2016-2019）
7. 職業低濃度苯暴露的血液毒性機制和毒作用模式研究 國家自然科學基金重點項目 （課題主持人 2015-2019）
8. 化學緻癌表觀遺傳調控模式研究 國家傑出青年基金（課題主持人 2010-2013）
9. 職業衛生檢測與健康監護技術研究  衛生公益性行業科研專項 （單元負責人 2010-2013）
10. 惡性腫瘤非編碼RNA相關蛋白的功能網絡與調控機制的研究 國家重點基礎研究計劃(973)項目 (骨幹 2010-2014)
11. 環境遺傳毒性物質暴露和效應評估關鍵技術 863計劃重大專項（分題負責人 2008-2011）
12. 環境化學污染物誘導細胞轉化的表觀遺傳機制. 國家自然科學基金重點項目 （課題主持人 2007-2010, 30630055）

【發表的主要論著】(代表作)

1.  Ziwei Wang, Shen Chen, Yaqin Pang, Lizhu Ye, Qi Zhang, Xinhang Jiang, Rui Zhang, Miao Li, Zhanyu Guo, Yue Jiang, Daochuan Li, Xiumei Xing, Liping Chen, Michael Aschner*, Wen Chen*. Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical induced toxicity. Arch Toxicol, 2023, 97:1133-1146.
2.  Rui Zhang, Shen Chen, Ziwei Wang, Lizhu Ye, Yue Jiang, Miao Li, Xinhang Jiang, Hui Peng, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li*, and Wen Chen*. Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Sub-chronically Exposed to Ambient Particulate Matter. Environ Health Perspect, 2023; 131(7):77006. 
3.  Shen Chen, Miao Li, Rui Zhang, Lizhu Ye, Yue Jiang, Xinhang Jiang, Hui Peng, Ziwei Wang, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li, Wen Chen*. Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM2.5-induced lung injury: a comparative study. Particle Fibre Toxicol, 2023, 20（1）:10.
4.  Liping Chen, Ping Guo, Wenxue Li, Xinhang Jiang, Qun Zhao, Daochuan Li，Qing Wang, Yongmei Xiao, Xiumei Xing, Michael Aschner, Lihua Zhang*, and Wen Chen*. Identification of Protein Phosphatase 2A-regulated Hepatic Metabolic Enzymes in Response to Xenobiotics. J Biol Chem, 2022; 298(5):101918.
5.  Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li*, and Wen Chen*. Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure. Part Fibre Toxicol, 2022; 19:42.
6.   Lizhu Ye, Zhini He, Daochuan Li, Liping Chen, Shen Chen, Ping Guo, Dianke Yu, Yong Niu, Huawei Duan, Xiumei Xing, Yongmei Xiao, Xiaowen Zeng, Qing Wang, Guanghui Dong, Michael Aschner, Yuxin Zheng*, Wen Chen*. CpG sites-specific methylation as epi-biomarkers for prediction of health risk in PAH-exposed populations. J Hazard Mater, 2022; 5; 431:128538.
7.   Lizhu Ye, Zhini He, Daochuan Li, Liping Chen, Shen Chen, Ping Guo, Dianke Yu, Yong Niu, Huawei Duan, Xiumei Xing, Yongmei Xiao, Xiaowen Zeng, Qing Wang, Guanghui Dong, Michael Aschner, Yuxin Zheng*, Wen Chen*. CpG sites-specific methylation as epi-biomarkers for prediction of health risk in PAH-exposed populations. J Hazard Mater, 2022; 5; 431:128538.
8.   Shen Chen, Daochuan Li, Xiaonen Wu, Liping, Chen, Bin Zhang, Yafei Tan, Dianke Yu, Yong Niu, Huawei Duan, Qiong Li, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen*. The Application of Cell-based Biological Endpoints for Health Risk Assessment of PM2.5 Exposure in Three Megacities, China. Environ Int, 2020; 139:105703.
9.  Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiaowen Zeng, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen*. Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol, 2020;17: 22.
10.  Chen S, Li DC, Zhang HY, Yu, DK, Chen R, Zhang B, Tan YF, Niu Y, Duan HW, Mai BX, Chen, SJ, Yu JZ, Luan TG, Chen LP, Xing XM, Li Q, Xiao YM, Dong GH, Niu YJ, Michael Aschner, Zhang R, Zheng YX, Chen W*. The Development of a Cell-based Model for The Assessment of Carcinogenic Potential Upon Long-term PM2.5 Exposure. Environ Int. 2019; 131:104943.
11.  Liang B, Chen Y, Yuan W, Qin F, Zhang Q, Deng N, Liu X, Ma X, Zhang X, Zhang B, Deng Q, Huang M, Tang H, Liu L, Chen W*, Xiao Y*. Down-regulation of miRNA-451a and miRNA-486-5p Involved in Benzene-induced Inhibition on Erythroid Cell Differentiation In Vitro And In Vivo. Arch Toxicol. 2018; 92:259-272.
12.  Li H, Li D, He Z, Fan J, Li Q, Liu X, Guo P, Zhang H, Chen S, Li Q, Zhang R, Xing X, Zeng X, Zhang A, Tang H, Dong G, Wang Q, Xiao Y, Chen L*, Chen W*. The Effects of Nrf2 Knockout on Regulation of Benzene-induced Mouse Hematotoxicity. Toxicol Appl Pharmacol, 2018; 358:56-67.
13.  Zhini He, Daochuan Li, Junxiang Ma, Liping Chen, Huawei Duan, Bo Zhang, Chen Gao, Jie Li, Xiumei Xing, Jian Zhao, Shan Wang, Fangping Wang, Haiyan Zhang, Huiyao Li, Shen Chen, Xiaowen Zeng, Qing Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen*. TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollution, 2017; 225:93-103.
14.  Lu Ma, Jun Li, Zhengbao Zhang, Liping Chen, Daochuan Li, Qing Bai, Chen Gao, Jie Li, Xiaowen Zeng, Zhine He, Shang Wang, Yongmei Xiao, Wen Chen*, Aihua Zhang*. Specific Histone Modification Responds to Arsenic-induced Oxidative Stress. Toxicol Appl Pharmacol, 2016; 302:52-61.
15.  LP Chen, L Ma, Q Bai, XN Zhu, JM Zhang, Q Wei, DC Li, C Gao, ZB Zhang, CX Liu, ZN He, XW Zeng, AH Zhang, WD Qu, Zhixiong Zhuang, Wen Chen*, and YM Xiao*. Heavy Metal-Induced Metallothionein Expression Is Regulated by Specific Protein Phosphatase 2A Complexes. J Biol Chem, 2014; 289(32):22413-26.
16.  P Yang, JX Ma, B Zhang, HW Duan, ZN He, JL Zeng, XW Zeng, DC Li, Q Wang, YM Xiao, CX Liu, Q Xiao, LP Chen, XN Zhu, XM Xing, ZF Li, SX Zhang, ZB Zhang, L Ma, EM Wang, ZX Zhuang, YX Zheng*, Wen Chen*. CpG Site-Specific Hypermethylation of p16INK4 In Peripheral Blood Lymphocytes of PAH-Exposed Workers. Cancer Epidem Biomar, 2012; 21(1):182-90.
17.  DC Li, Q Wang, CX Liu, HW Duan, XW Zeng, B Zhang, XD Li, J Zhao, SF Tang, ZF Li, XM Xing, P Yang, LP Chen, JL Zeng, XN Zhu, SX Zhang, ZB Zhang, L Ma, ZN He, EM Wang, YM Xiao, YX Zheng, W Chen*. Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene–induced Human Cell Transformation. Toxicol Sci, 2012; 125(2): 382-91.
18.  L-P Chen, Y-D Lai, D-C Li, X-N Zhu, P Yang, W-X Li, W Zhu, J Zhao, X-D Li, Y-M Xiao, Y Zhang, X-M Xing, Q Wang, B Zhang, Y-C Lin, J-L Zeng, S-X Zhang, C-X Liu, Z-F Li, X-W Zeng, Z-N Lin, Z-X Zhuang, and W Chen*. Alpha4 Is Highly Expressed In Carcinogen-transformed Human Cells And Primary Human Cancers. Oncogene, 2011; 30(26):2943-2953.
19.  Q Wang, D-C Li, Z-F Li, C-X Liu, Y-M Xiao, B Zhang, X-D Li, J Zhao, L-P Chen, X-M Xing, S-F Tang, Y-C Lin, Y-D Lai, P Yang, J-L Zeng, Q Xiao, X-W Zeng, Z-N Lin, Z-X Zhuang and W Chen*. Upregulation of miR-27a Contributes to the Malignant Transformation of Human Bronchial Epithelial Cells Induced by SV40 Small T Antigen. Oncogene, 2011; 30(36):3875-86. 32.    
20.  Pang YQ, Ma RL, Li WX, Wang Q, Li DC, Xiao YM, Wei Q, Lin YC, Lai YD, Yang P, Tang S, Zhuang ZX, Zheng YX, Chen W*. Development of Human Cell Models for Assessing the Carcinogenic Potential of Chemicals. Toxicol Appl Pharm, 2008, 232:478-86. 
21. Ji WD, Yang LQ, Yu L, Yuan JH, Hu DL, Zhang WJ, Yang JP, Pang YQ, Li WX, Lu JC, Fu J, Chen JK, Lin ZN, Chen W*, Zhuang ZX*. Epigenetic Silencing of O6-methylguanine-DNA Methyltransferase Gene in NiS-transformed Cells. Carcinogenesis, 2008; 29(6):1267-75.
22.  Sablina AA, Chen W (co-first author), Arroyo JD, Laura Corral, Melissa Hector, Sara E. Bulmer James A. DeCaprio, and Hahn WC. The Tumor Suppressor PP2A Abeta Regulates The RalA GTPase. Cell, 2007; 129: 969-82. 
23.  Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, and Hahn WC. Identification of Specific PP2A Complexes Involved in Human Cell Transformation. Cancer Cell, 2004; 5(2):127-36. 
24.  Chen W, Zhou YG, Nichols J, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Benzo[a]pyrene Metabolic Activation and Pulmonary BaP-DNA Adduct Formation in Mouse. Drug Chem Toxicol, 1996; 19(1&2):21-39.
25.   Chen W, Nichols J, Zhou YG, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Glutathione S-transferase Activity Specific Toward Aflatoxin B1-8,9-epoxide. Toxicol Lett, 1995; 78:235-43.

【研究生培養情況】

博士生畢業24名
碩士生畢業48名

【招生專業】

衛生毒理學
勞動衛生與職業病

【獲獎情況】

全國優秀科技工作者 2014年
中國毒理學傑出貢獻獎 2017年