【職稱】副教授,碩士生導師

【學位/學曆】
 2016/09-2020/10,研究生學曆 博士學位
 2012/09-2016/07,本科學曆   學士學位

【學習經曆】
 2016/09-2020/10,香港大學生物科學學院 生物信息及系統生物學
 2012/09-2016/07,太阳集团app首页生命科學學院 生物技術

【工作經曆】
 2020/12-2023/12 香港大學李嘉誠醫學院 生物醫藥技術國家重點實驗室 博士後
 2020/09-2024/02 德國萊布尼茨天然産物研究和感染生物學研究所 微生物組動力學部 訪問學者

【研究方向及興趣】
  長期從事生物信息學及多組學聯合分析研究(宏基因組、代謝組、脂質組、蛋白質組等)。依托所在研究團隊所建立的華南地區前瞻性自然人群隊列,聚焦于“代謝綜合征的早期防治”核心科學問題,綜合性探索“營養代謝-腸道菌群-宿主代謝健康”之間的動态聯系,緻力于(1)篩選代謝綜合征的新型生物标志物;(2)發現關鍵緻病通路及分子機制;(3)構建代謝綜合征早期風險預測模型。

【論文代表作(近五年)】
1. Chen J*, Siliceo SL*, Ni Y, Nielsen HB, Xu A#, Panagiotou G#. Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions. Microbiome. 2023 Aug 8;11(1):178. (IF=15.5)
2. Chen J*, McIlroy SE*, Archana A, Baker DM#, Panagiotou G#. A pollution gradient contributes to the taxonomic, functional, and resistome diversity of microbial communities in marine sediments. Microbiome. 2019 Dec;7:1-2. (IF=15.5)
3. Chen J*, Lu RS*, Diaz-Canestro C, Song E, Jia X, Liu Y, Wang C, Cheung CK, Panagiotou G, Xu A#. Distinct changes in serum metabolites and lipid species in the onset and progression of NAFLD in Obese Chinese. Computational and Structural Biotechnology Journal. 2024 Dec 1;23:791-800. (IF=6.0)
4. Seelbinder B*, Chen J*, Brunke S, Vazquez-Uribe R, Santhaman R, Meyer AC, de Oliveira Lino FS, Chan KF, Loos D, Imamovic L, Tsang CC, Panagiotou G#. Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome. 2020 Dec;8:1-20. (IF=15.5)
5. Wang Y*, Chen J*, Ni Y, Liu Y, Gao X, Ma Tse, Panagiotou G#, Xu A#. Exercise-changed gut mycobiome as a potential contributor to metabolic benefits in diabetes prevention: an integrative multi-omics study. Gut Microbes. 2024 Dec 16(1). (IF=12.2)
6. Nie X*, Chen J*, Ma X, Ni Y, Shen Y, Yu H, Panagiotou G#, Bao Y#. A metagenome-wide association study of gut microbiome and visceral fat accumulation. Computational and Structural Biotechnology Journal. 2020 Jan 1;18:2596-609. (IF=6.0)
7. Zhang L*, Li H*, Sun F, Wu Q, Jin L, Xu A, Chen J#, Yang R#. Identification of novel markers for neuroblastoma immunoclustering using machine learning. Frontiers in Immunology. 2024 Nov 4;15:1446273. (IF = 5.7)
8. Diaz-Canestro C*, Chen J*, Liu Y, Han H, Wang Y, Honore E, Lee CH, Lam KS, Tse MA, Xu A#. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Reports Medicine. 2023 Feb 21;4(2). (IF=14.3)
9. Jia X*, Song E*, Liu Y, Chen J, Wan P, Hu Y, Ye D, Chakrabarti S, Mahajan H, George J, Yan S, Xu A#. Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese. Cell Reports Medicine. 2023 Nov 21;4(11). (IF=14.3)
10. Xu L*, Mcllroy SE*, Ni Y, Guibert I, Chen J, Rocha U, Baker D#, Panagiotou G#. Chemical pollution drives taxonomic and functional shifts in marine sediment microbiome, influencing benthic metazoans. ISME Communications. 2025 Feb 13: ycae141. (IF = 5.1)
11. Zhang F*, Lo EKK*, Chen J, Wang K, Felicianna, Ismaiah MJ, Leung HKM, Zhao D#, Lee JCY#, El-Nerzami H#. Probiotic mixture ameliorates a diet-induced MASLD/MASH murine model through the regulation of hepatic lipid metabolism and the gut microbiome. Journal of Agricultural and Food Chemistry. 2024 April 4: 72(15). (IF = 5.7)
 

【參編論著】
1. Chen J*, Wang Y, Xu A, Panagiotou G. The human gut mycobiome and its potential as a regulator of the host's metabolic health. Human and Animal Relationships. 2024 Nov 24: pp. 121-133


【研究項目】
1. 2023年度香港醫療衛生研究基金(HMRF),“Mapping the human gut mycobiome for the metabolic benefits of exercise in diabetes prevention”,130萬元,在研,第二參與人
2. 太阳集团app首页引進人才基本啟動經費,主持
3. 國家自然科學基因青年科學基金項目,“Eubacterium eligens菌調控肝髒組織胰島素抵抗延緩代謝性脂肪肝病進展的作用及其機制研究”, 30萬元,在研,主持


【獲獎情況】
1. 2020年11月,medac醫學研究獎,Lebniz-HKI,第二獲獎人
2. 2016年-2020年,香港大學研究生獎學金


【社會兼職】
1. Computational and Structural Biotechnology Journal、Frontiers in Cellular and Infection Microbiology等雜志審稿人
2. 中國病理生理學會内分泌與代謝專委會會員
2. 中國營養學會組學分會委員