【個人簡曆】

郭城博士多年來聚焦病原組學檢測技術的創新，以及其在新發和不明原因感染性疾病研究中的應用，包括：①發明病原捕獲測序和高通量血清學檢測技術，利用創新的探針設計、樣本處理體系和生信分析流程，使新方法的靈敏度較傳統方法提升近千倍；②在臨床或自然場景中開展新發傳染病的檢測和風險預警研究，助力公共衛生政策的調整；③鑒定以慢性疲勞綜合征為代表的不明原因感染性疾病的腸道細菌生物标志物，揭示了丁酸鹽産生菌在疾病進展中的作用。近年來在Cell Host Microbe，Lancet Gastroenterol等雜志發表論文40餘篇，被引用3500餘次，獲批多項與病原檢測相關的美國發明專利。相關科研成果曾被國家新冠防控指南引用、以及時代雜志、紐約日報、财新新聞等100多家新聞媒體報道。

課題組主頁：https://lab.chengguo-sysu.cn/

 

【工作經曆】
2024至今，太阳集团app首页，太阳集团1088vip，副教授
2022/10-2024，哥倫比亞大學(Columbia University)，太阳集团1088vip，感染免疫研究中心生信團隊負責人(Head of Bioinformatics)
2016/05-2024/03，哥倫比亞大學，太阳集团1088vip，高級生信研究員(Senior Programmer Analyst/Bioinformatics)
2015/01-2016/05，美國國家環境保護署(EPA)，生物信息師(Bioinformatician)

 

【學習經曆】
2011/09-2016/10，邁阿密大學(Miami University), 生物信息學，博士
2008/09-2011/06，中國藥科大學，藥物生物信息學，碩士
2004/09-2008/06，中國藥科大學，生命科學基地班，學士

 

【研究生招生與博士後招聘】
博士/碩士研究生 (方向：公共衛生與預防、醫學流行病與衛生統計學、公共衛生碩士MPH等相關學科)
博士後 (方向：病原學、微生物組、生物信息學等相關學科)

 

【近年論文代表作】

  • C. Guo, J. Y. Wu. Pathogen Discovery in the Post-COVID Era. Pathogens, 2024, 13(1)
  • X Li, C Liao, J Wu, B Yi, R Zha, Q Deng, J Xu, C Guo#, J Lu#, Distinct serum exosomal miRNA profiles detected in acute and asymptomatic dengue infections: A community-based study in Baiyun District, Guangzhou, Heliyon 10 (10)
  • C. Guo, X. Che, T. Briese, A. Ranjan, O. Allicock, R. A. Yates et al. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host Microbe, 2023, 31(2): 288-304.e8
  • C. Guo, B. Yi, J. Wu, J. Lu. The microbiome in post-acute infection syndrome (PAIS). Computational and structural biotechnology journal, 2023, 21: 3904-3911
  • Q. Wu*, C. Guo*, X. K. Li, B. Y. Yi, Q. L. Li, Z. M. Guo et al. A meta-transcriptomic study of mosquito virome and blood feeding patterns at the human-animal-environment interface in Guangdong Province, China. One health (Amsterdam, Netherlands), 2023, 16: 100493
  • X. Cheng, Y. Zhang, Y. Li, Q. Wu, J. Wu, S. K. Park, C. Guo#, J. Lu#. Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases. BMC Microbiology, 2022, 22(1): 1-13
  • Y. Wu, X. Cheng, G. Jiang, H. Tang, S. Ming, L. Tang, C. Guo#, H. Shan#, X. Huang#. Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization. NPJ biofilms and microbiomes, 2021, 7(1): 61
  • J. Y. Wu*, C. Guo*, Y. Xia, H. M. Bao, Y. S. Zhu, Z. M. Guo et al. Genomic characterization of Wenzhou mammarenavirus detected in wild rodents in Guangzhou City, China. One health (Amsterdam, Netherlands), 2021, 13: 100273
  • J. Wang*, C. Guo*, L. Cai, C. Liao, H. Yi, Q. Li et al. Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization. Frontiers in immunology, 2021, 12: 772511
  • J. Y. Wu*, Y. S. Zhu*, C. Guo*, Y. Xia, Z. M. Guo, Q. L. Li et al. A Comparative Study of Associated Microbiota Between Pig Farm and Pig Slaughterhouse in Guangdong, China. Current microbiology, 2020, 77(11): 3310-3320
  •  Y. Wu*, C. Guo*, L. Tang, Z. Hong, J. Zhou, X. Dong et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The lancet. Gastroenterology & hepatology, 2020, 5(5): 434-435
  •  M. Allicock*, C. Guo*, A. C. Uhlemann, S. Whittier, L. V Chauhan, J. Garcia et al. BacCapSeq: a Platform for Diagnosis and Characterization of Bacterial Infections. mBio, 2018, 9(5)
  •  C. Guo, M. Spinelli, M. Liu, Q. Q. Li, C. Liang. A Genome-wide Study of “Non-3UTR” Polyadenylation Sites in Arabidopsis thaliana. Scientific Reports, 2016, 6: 28060
  •  C. Guo, M. Spinelli, C. Ye, Q. Q. Li, C. Liang. Genome-Wide Comparative Analysis of Miniature Inverted Repeat Transposable Elements in 19 Arabidopsis thaliana Ecotype Accessions. Scientific reports, 2017, 7(1): 2634
  •  L. Li*, C. Guo*, C. Liang, X. Wang. RNAi-mediated transgenic rice resistance to Rice stripe virus. Journal of integrative Agriculture, 2016, 23
  •  C. Guo, L. Li, X. Wang, C. Liang. Alterations in SiRNA and MiRNA Expression Profiles Detected by Deep Sequencing of Transgenic Rice with SiRNA-Mediated Viral Resistance. PLOS ONE, 2015, 10(1): e0116175
  •  L. Ma, C. Guo, Q. Q. Li. Role of alternative polyadenylation in epigenetic silencing and antisilencing. Proceedings of the National Academy of Sciences, 2014, 111(1): 9-10