學位/學曆： 
衛生毒理學 醫學博士

學術簡曆： 
【學習經曆】
2015.09 – 2020.06 太阳集团1088vip 衛生毒理學 醫學博士
2010.09 – 2015.06 太阳集团1088vip 預防醫學   醫學學士
【工作經曆】
2023.12 – 至今   太阳集团1088vip 副教授
2022.07 – 2023.11 太阳集团1088vip 副研究員
2020.07 – 2022.07 太阳集团1088vip 博士後
  
 研究方向：
　　主要從事環境毒理與健康研究，緻力于環境污染物的體外評價模型構建、毒效應分子機制和幹預措施研究。主持國家自然科學基金項目1項，省部級項目3項，作為骨幹參與國家自然科學基金重點項目。以第一/共一作者在Environ Health Perspect、Environ Int、Part Fibre Toxicol、J Hazard Mater、Arch Toxicol、Toxicol Sci等環境毒理學權威期刊發表SCI論文。

論文代表作（#第一作者，*通訊作者）： 
1. Zhang R#, Chen S#, Wang ZW#, Ye LZ, Jiang Y, Li M Jiang XH, Peng H, Guo ZY, Chen LP, Zhang R, Niu YJ, Aschner M, Li DC*, Chen W*. Assessing the effects of nicotinamide mononucleotide supplementation on pulmonary inflammation in male mice subchronically exposed to ambient particulate matter. Environ Health Perspect. 2023 Jul;131(7):77006.
2. Chen S#, Li M#, Zhang R#, Ye LZ, Jiang Y, Jiang XH, Peng H, Wang Z, Guo ZY, Chen LP, Zhang R, Niu YJ, Aschner M, Li DC, Chen W*. Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM2.5-induced lung injury: a comparative study. Part Fibre Toxicol. 2023 Apr 17; 20(1):10.
3. Wang ZW#, Chen S#, Pang YQ#, Ye LZ, Zhang Q, Jiang XH, Zhang R, Li M, Guo ZY, Jiang Y, Li DC, Xing XM, Chen LP, Aschner M*, Chen W*. Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity. Arch Toxicol. 2023 Apr; 97(4):1133-1146.
4. Zhang Rui#, Chen S#, Chen LP#, Ye LZ, Jiang Y, Peng H, Guo ZY, Li M, Jiang XH, Guo P, Yu DK, Zhang R, Niu YJ, Zhuang Y, Aschner M, Zheng YX, Li DC*, Chen W*. Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure. Part Fibre Toxicol. 2022 Jun 23; 19(1):42.
5. Chen S#, Li DC#, Yu DK, Li M, Ye LZ, Jiang Y, Tang SJ, Zhang R, Xu C, Jiang SY, Wang ZW, Aschner M, Zheng YX, Chen LP*, Chen W*. Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers. J Hazard Mater. 2022 Mar 15; 426:128089.
6. Chen S#, Chen LP#, Ye LZ#, Jiang Y, Li Q, Zhang HY, Zhang R, Li HY, Yu DK, Zhang R, Niu Y, Zhao Q, Liu JH, Ouyang GF, Aschner M, Zheng YX, Zhang LH, Chen W*, Li DC*. PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater. 2022 Feb 15; 424 (Pt C):127624.
7. Chen S, Tang Y, Fang WJ, He TP, Chen X*, Zhang PW*. CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. Toxicol Sci. 2021 Dec 28;185(1):19-27.
8. Zhang PW#, Chen S#, Tang HW, Fang WJ, Chen K, Chen X*. CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy. Toxicol Appl Pharmacol. 2021 Jan 1; 410:115355.
9. Chen S#, Li DC#, Wu XN#, Chen LP, Zhang B, Tan YF, Yu DK, Niu Y, Duan HW, Li Q, Chen R, Aschner M, Zheng YX, Chen W*. Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environ Int. 2020 Jun; 139:105703.
10. Li DC#, Chen S#, Li Q#, Chen LP, Zhang HY, Li HY, Yu DK, Zhang R, Niu YJ, Lu SY, Ye LZ, Zeng XW, Dong GH, Chen R, Aschner M, Zheng YX, Chen W*. Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol. 2020 Jun 5;17(1):22.
11. Guo P#, Chen S#, Li DC, Zhang JM, Luo J, Zhang AH, Yu DK, Michael S Bloom, Chen LP*, Chen W. SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes. Environ Pollut. 2020 Jun; 261:114160.
12. Chen S#, Li DC#, Zhang HY#, Yu DK, Chen R, Zhang B, Tan YF, Niu Y, Duan HW, Mai BX, Chen SJ, Yu JZ, Luan TG, Chen LP, Xing XM, Li Q, Xiao YM, Dong GH, Niu YJ, Aschner M, Zhang R, Zheng YX, Chen W*. The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int. 2019 Oct; 131:104943.

主要承擔或參與的課題：
2023.01 – 2025.12 國家自然科學基金青年基金項目 主持人
2023.01 – 2025.12 廣東省自然科學基金面上項目   主持人
2024.01 – 2025.12 廣州市基礎與應用基礎研究項目 主持人
2022.01 – 2026.12 國家自然科學基金重點項目     參與人
2020.07 – 2022.06 中國博士後面上項目           主持人

參編教材與論著： 
1. 《現代毒理學》[M]. 人民衛生出版社
2. 《基于毒作用模式的典型環境污染物風險評估》[M]. 太阳集团app首页出版社