【學術簡曆】
2002/09-2005/07 軍事醫學科學院 博士學位
1999/09-2002/07 解放軍軍需大學 碩士學位
1995/09-1999/06 解放軍農牧大學 學士學位
先後任軍事醫學科學院疾病預防控制所助理研究員（2005-2007）、副研究員（2007-2014）及研究員（2014-2016）、解放軍公共衛生應急處置大隊偵檢隊隊長（2010-2016）、軍事醫學科學院疾病預防控制所傳染病控制中心副主任（2010-2016）、天康生物股份有限公司研發中心創新團隊首席專家（2017-2020）、遼甯省人獸共患病研究重點實驗室副主任（2017-），2020年至今于太阳集团1088vip流行病與衛生統計學系任教，特聘副教授，博士生導師。
入選省級高層次人才計劃，長期以來主要從事疾病預防控制工作及相關研究，先後主持國家重點研發計劃項目課題、國家863專題、國家自然科學基金重點項目、傳染病重大專項子任務課題等科研項目10餘項，先後發表SCI論文90餘篇，授權專利10項，獲批新獸藥證書1項，診斷産品CE證書10項。
【招生方向】
流行病與衛生統計學
【社會兼職】
中國醫學會地方病學會理事
中國微生物學會分析微生物委員
中國地方病防治雜志編委
【主要承擔或參與的課題（5-6項代表性課題）】
1.2020.01-2022.12，布魯氏菌緻反刍動物流産的風險因素與作用機制研究，國家自然自然科學基金國際（地區）合作與交流項目，175萬（主持人）
2.2019.01-2022.12，反刍動物布魯氏菌病免疫預防的基礎研究，國家自然科學基金重點項目, 246萬（主持人）
3.2017.07-2020.12，病原菌逃逸宿主免疫與胞内存活的分子機制，國家重點研發計劃項目,485萬（主持人）
4.2019.07-2022.12，人畜間布病綜合防控技術集成與示範，内蒙古自治區重大科技專項，1430萬（主持人）
5.2016.01-2018.12，動物源性微生物變異機制與播散規律，國家重點研發計劃項目，298萬（子課題負責人）
【近期發表的主要文章，*通信作者】
2020年
1. Niu Y, Yang L, Gao T, Dong C, Zhang B, Yin P, Hopp AK, Li D, Gan R, Wang H, Liu X, Cao X, Xie Y, Meng X, Deng H, Zhang X, Ren J, Hottiger MO, Chen Z*（并列通訊）, etc. A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation. Mol Cell. 2020 Oct 6:S1097-2765(20)30645-6. doi: 10.1016/j.molcel.2020.09.015. Online ahead of print.
2. Zhang Q, Li C, Wang Y, Li Y, Han X, Zhang H, Wang D, Liao Y, Chen Z*. Temporal and spatial distribution trends of human brucellosis in Liaoning Province, China.Transbound Emerg Dis. 2020, doi: 10.1111/tbed.13739.
3. Wang J, Li Z, Cheng X, Hu H, Liao C, Li P, Lu J, Chen Z*. Epidemiologic Characteristics, Transmission Chain, and Risk Factors of Severe Infection of COVID-19 in Tianjin, a Representative Municipality City of China. Front Public Health. 2020 May 20;8:198.
4. Liu J, Lu G, Cui Y, Wei S, An T, Shen G, Chen Z*.An insight into the transmission role of insect vectors based on the examination of gene characteristics of African swine fever virus originated from non-blood sucking flies in pig farm environments. BMC Vet Res. 2020 Jul 2;16(1):227.
5. Tao D, Sun D, Liu Y, Wei S, Yang Z, An T, Shan F, Chen Z*, Liu J. One year of African swine fever outbreak in China. Acta Trop. 2020 Jun 26;211:105602.
6. Baoshan L, Yinbo Y, Jingbo Z, Yi Z, Jianghua Y, Dawei C, Chi M, Donghai Y, Bohan Y, Rongnian Z, Sheng F, Jun Z, Han X, Chen Z*. Combined nucleic acid assays for diagnosis of A19 vaccine-caused human brucellosis. Transbound Emerg Dis. 2020 Jun 16. doi: 10.1111/tbed.13685.
7. Chen ZL, Zhang Q, Lu Y, Guo ZM, Zhang X, Zhang WJ, Guo C, Liao CH, Li QL, Han XH, Lu JH. Distribution of the COVID-19 epidemic and correlation with population emigration from Wuhan, China. Chin Med J (Engl). 2020 May 5;133(9):1044-1050.
8. Chen ZL, Zhang WJ, Lu Y, Guo C, Guo ZM, Liao CH, Zhang X, Zhang Y, Han XH, Li QL, Lu JH. From severe acute respiratory syndrome-associated coronavirus to 2019 novel coronavirus outbreak: similarities in the early epidemics and prediction of future trends.Chin Med J (Engl). 2020 May 5;133(9):1112-1114.
9. Liu J, Liu B, Shan B, Wei S, An T, Shen G, Chen Z*. Prevalence of African Swine Fever in China, 2018-2019. J Med Virol. 2020 Aug;92(8):1023-1034.
2019年
10. Zhang TT, Liu MZ, Yin RH, Yao LQ, Liu BS, Chen ZL*. Rapid and simple detection of Glaesserella parasuis in synovial fluid by recombinase polymerase amplification and lateral flow strip. BMC Vet Res. 2019 Aug 14;15(1):294.
11. Xu H, Zhang Q, Guan H, Zhong Y, Jiang F, Chen Z*, Han X. High Incidence of a Novel Rickettsia Genotype in Parasitic Haemaphysalis longicornis from China-North Korea Border. Sci Rep. 2019 Mar 29;9(1):5373. doi: 10.1038/s41598-019-41879-7.
12. Wang Y, Ke Y, Duan C, Ma X, Hao Q, Song L, Guo X, Sun T, Zhang W, Zhang J, Zhao Y, Zhong Z, Yang X, Chen Z*. A small non-coding RNA facilitates Brucella melitensis intracellular survival by regulating the expression of virulence factor. Int J Med Microbiol. 2019 May - Jun;309(3-4):225-231.
13. Liu MZ, Han XH, Yao LQ, Zhang WK, Liu BS, Chen ZL*. Development and application of a simple recombinase polymerase amplification assay for rapid point-of-care detection of feline herpesvirus type 1. Arch Virol. 2019 Jan;164(1):195-200.
2018年
14. S Ding, X Han, J Li, W Gao, Z Chen*, Y Feng. Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China. Science Bulletin. 2018, 63:16, 1059-1066.
2017年
15. Yang M, Ke Y, Zhang W, Liu C, Yang R, Chen Z*. RT-PCR using glycoprotein target is more sensitive for the detection of Ebola virus in clinical samples. Diagn Microbiol Infect Dis. 2017 Mar;87(3):235-237.
16. Liu SW, Xu XY, Xu J, Yuan JY, Wu WK, Zhang N, Chen ZL*. Multi-drug resistant uropathogenic Escherichia coli and its treatment by Chinese medicine. Chin J Integr Med. 2016 Dec 27. doi: 10.1007/s11655-016-2738-0.
2016年
17. Li W, Ke Y, Wang Y, Yang M, Gao J, Zhan S, Xinying D, Huang L, Li W, Chen Z*, Li J. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.Biochem Biophys Res Commun. 2016 Jun 13. doi: 10.1016/j.bbrc.2016.06.064.
18. Ke Y, Li W, Wang Y, Yang M, Guo J, Zhan S, Du X, Wang Z, Yang M, Li J, Li W, Chen Z*. Inhibition of TLR4 signaling by Brucella TIR-containing protein TcpB-derived decoy peptides.Int J Med Microbiol. 2016 Sep;306(6):391-400.
19. Yang M, Ke Y, Wang X, Ren H, Liu W, Lu H, Zhang W, Liu S, Chang G, Tian S, Wang L, Huang L, Liu C, Yang R, Chen Z*.Development and Evaluation of a Rapid and Sensitive EBOV-RPA Test for Rapid Diagnosis of Ebola Virus Disease. Sci Rep. 2016 Jun 1;6:26943.
20. Zhong Z, Xu X, Li X, Liu S, Lei S, Yang M, Yu J, Yuan J, Ke Y, Du X, Wang Z, Ren Z, Peng G, Wang Y, Chen Z*.Large-scale identification of small noncoding RNA with strand-specific deep sequencing and characterization of a novel virulence-related sRNA in Brucella melitensis. Sci Rep. 2016 Apr 26;6:25123.
21. Wang X, Li X, Liu S, Ren H, Yang M, Ke Y, Huang L, Liu C, Liu B, Chen Z*: Ultrasensitive Detection of Bacteria by Targeting Abundant Transcripts. Sci Rep 2016, 6:20393.
22. Ren H, Yang M, Zhang G, Liu S, Wang X, Ke Y, Du X, Wang Z, Huang L, Liu C, Chen Z*: Development of a rapid recombinase polymerase amplification assay for detection of Brucella in blood samples. Mol Cell Probes. 2016 Apr;30(2):122-4.
23. Chen Z, Liang H, Chen X, Ke Y, Zhou Z, Yang M, Zen K, Yang R, Liu C, Zhang C-Y: An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease. Cell Res. 2016 Mar;26(3):380-3.
24. Lei S, Zhong Z, Ke Y, Yang M, Xu X, Ren H, An C, Yuan J, Yu J, Xu J, Qiu Y, Shi Y, Wang Y, Peng G, Chen Z*.Deletion of the Small RNA Chaperone Protein Hfq down Regulates Genes Related to Virulence and Confers Protection against Wild-Type Brucella Challenge in Mice. Front Microbiol. 2016 Jan 20;6:1570.
2015年
25. Wang Y, Ke Y, Xu J, Wang L, Wang T, Liang H, Zhang W, Gong C, Yuan J, Zhuang Y, An C, Lei S, Du X, Wang Z, Li W, Yuan X, Huang L, Yang X, Chen Z*: Identification of a Novel Small Non-Coding RNA Modulating the Intracellular Survival of Brucella melitensis. Front Microbiol 2015, 6:164.
26. Wang X, An C, Yang M, Li X, Ke Y, Lei S, Xu X, Yu J, Ren H, Du X, Wang Z, Qiu Y, Liu B, Chen Z*: Immunization with individual proteins of the Lrp/AsnC family induces protection against Brucella melitensis 16M challenges in mice. Front Microbiol 2015, 6:1193.
27. Ke Y, Wang Y, Li W, Chen Z*: Type IV secretion system of Brucella spp. and its effectors. Front Cell Infect Microbiol 2015, 5:72.
28. Chen Z, Chang G, Zhang W, Chen Y, Wang X, Yang R, Liu C: Mobile laboratory in Sierra Leone during outbreak of Ebola: practices and implications. Sci China Life Sci 2015, 58(9):918-921.
2013年
29. Zhen Q, Lu Y, Yuan X, Qiu Y, Xu J, Li W, Ke Y, Yu Y, Huang L, Wang Y, Chen Z*: Asymptomatic brucellosis infection in humans: implications for diagnosis and prevention. Clin Microbiol Infect 2013, 19(9):E395-397.
30. Zhang N, Huang L, Liu S, Wang Y, Luo Y, Jin X, Guo J, Ke Y, Chen J, Yuan X, Chen Z*: Traditional chinese medicine: an alternative treatment option for refractory recurrent urinary tract infections. Clin Infect Dis 2013, 56(9):1355.
31. Xu J, Qiu Y, Cui M, Ke Y, Zhen Q, Yuan X, Yu Y, Du X, Yuan J, Song H, Wang Z, Gao G, Yu S, Wang Y, Huang L, Chen Z*: Sustained and differential antibody responses to virulence proteins of Brucella melitensis during acute and chronic infections in human brucellosis. Eur J Clin Microbiol Infect Dis 2013, 32(3):437-447.
32. Wang Y, Zhang W, Ke Y, Zhen Q, Yuan X, Zou W, Li S, Sun Y, Wang Z, Wang D, Cui B, Song H, Huang L, Chen Z*: Human brucellosis, a heterogeneously distributed, delayed, and misdiagnosed disease in china. Clin Infect Dis 2013, 56(5):750-751.
33. Liu S, Zhang N, Chen Z*: Recurrent urinary tract infections caused by multidrug-resistant uropathogenic Escherichia coli: implications for diagnosis and treatment. Eur Urol 2013, 63(2):410-411.
34. Ke Y, Zhen Q, Wang Y, Yuan X, Li W, Lu Y, Qiu Y, Yu Y, Huang L, Chen Z*: Window of treatment initiation for human brucellosis, implications for treatment efficacy, and prevention of chronic infection. Clin Infect Dis 2013, 56(9):1350-1352.
35. Ke Y, Wang Y, Zhang W, Huang L, Chen Z*: Deaths associated with avian influenza A(H7N9) virus in China. Ann Intern Med 2013, 159(2):159-160.
36. Ke Y, Wang Y, Wang Z, Du X, Huang L, Chen Z*: Sensitive and rapid detection of blandm-1 in Clinical Samples by Isothermal Cross-Priming Amplification. J Microbiol Methods 2013.
37. Ke Y, Wang Y, Liu S, Guo J, Zhang W, Yuan X, Zhang N, Wang Z, Song H, Huang L, Chen Z*: High severity and fatality of human infections with avian influenza A(H7N9) infection in China. Clin Infect Dis 2013, 57(10):1506-1507.
38. Feng Y, Xu J, Zhang H, Chen Z*#, Srinivas S*#: Brucella BioR Regulator Defines a Complex Regulatory Mechanism for Bacterial Biotin Metabolism. J Bacteriol 2013, 195(15):3451-3467.
39. Cui M, Wang T, Xu J, Ke Y, Du X, Yuan X, Wang Z, Gong C, Zhuang Y, Lei S, Su X, Wang X, Huang L, Zhong Z, Peng G, Yuan J, Chen Z*#, Wang Y*#: Impact of Hfq on Global Gene Expression and Intracellular Survival in Brucella melitensis. PLoS One 2013, 8(8):e71933.
40. Chen Z, Zhang W, Ke Y, Wang Y, Tian B, Wang D, Cui B, Zou W, Li S, Huang L, Song H: High-risk regions of human brucellosis in china: implications for prevention and early diagnosis of travel-related infections. Clin Infect Dis 2013, 57(2):330-332.
41. Chen Z, Wang Y, Wang Z, Ke Y, Zhen Q, Yuan X, Zhang W, Lu Y, Yu Y, Song H, Huang L: Improvement and advancement of early diagnosis of human brucellosis in window period. Clin Infect Dis 2013, 57(2):322-323.
42. Chen Y, Ke Y, Wang Y, Yuan X, Zhou X, Jiang H, Wang Z, Zhen Q, Yu Y, Huang L, Cui B, Chen Z*: Changes of predominant species/biovars and sequence types of Brucella isolates, Inner Mongolia, China. BMC Infect Dis 2013, 13:514.
2012年
43. Zhong Z, Wang Y, Xu J, Chen Y, Ke Y, Zhou X, Yuan X, Zhou D, Yang Y, Yang R, Peng G, Jiang H, Yuan J, Song H, Cui B, Huang L, Chen Z*: Parallel gene loss and acquisition among strains of different Brucella species and biovars. J Microbiol 2012, 50(4):567-574.
44. Zhong Z, Wang L, Chen Y, Wang Z, Wang Y, Cui M, Li T, Ke Y, Yuan X, Wang D, Chen Z*#, Peng G*#: Complete genome sequence of Brucella abortus strain BCB034, a strain of biovar 2 isolated from human. J Bacteriol 2012, 194(24):6943.
45. Wang Y, Ke Y, Zhen Q, Yuan X, Xu J, Qiu Y, Wang Z, Li T, Wang D, Huang L, Chen Z*: Complete genome sequence of Brucella canis BCB018, a strain isolated from a human patient. J Bacteriol 2012, 194(23):6697-6698.
46. Wang Y, Ke Y, Wang Z, Yuan X, Qiu Y, Zhen Q, Xu J, Li T, Wang D, Huang L, Chen Z*: Genome sequences of three live attenuated vaccine strains of Brucella species and implications for pathogenesis and differential diagnosis. J Bacteriol 2012, 194(21):6012-6013.
47. Wang Y, Ke Y, Gao G, Zhen Q, Yuan X, Wang Z, Xu J, Li T, Wang D, Huang L, Xu X, Chen Z*: Complete genome sequence of Brucella abortus 134, a biovar 1 strain isolated from human. J Bacteriol 2012, 194(23):6658.
48. Song S, Yuan X, Liu S, Zhang N, Wang Y, Ke Y, Xu J, Huang L, Chen Z*#, Li Y*#: Genome sequence of Stenotrophomonas maltophilia S028, an isolate harboring the AmpR-L2 resistance module. J Bacteriol 2012, 194(23):6696.
49. Liu S, Wang Y, Xu J, Li Y, Guo J, Ke Y, Yuan X, Wang L, Du X, Wang Z, Huang L, Zhang N, Chen Z*: Genome sequence of an OXA23-producing, carbapenem-resistant Acinetobacter baumannii strain of sequence type ST75. J Bacteriol 2012, 194(21):6000-6001.
50. Li X, Xu J, Xie Y, Qiu Y, Fu S, Yuan X, Ke Y, Yu S, Du X, Cui M, Chen Y, Wang T, Wang Z, Yu Y, Huang K, Huang L, Peng G, Chen Z*#, Wang Y*#: Vaccination with recombinant flagellar proteins FlgJ and FliN induce protection against Brucella abortus 544 infection in BALB/c mice. Vet Microbiol 2012, 161(1-2):137-144.
51. Li T, Yuan X, Ding J, Zhen Q, Ke Y, Wang Y, Huang L, Mao K, Chen Z*#, Wang D*#: Genome sequence of Brucella melitensis strain 128, an isolate of biovar 3 of sequence type 8. J Bacteriol 2012, 194(24):6960.
52. Ke Y, Zhen Q, Li T, Wang Y, Yuan X, Xu J, Huang L, Wang D, Song H, Chen Z*: Complete genome sequence of Brucella melitensis 133, an isolate of biovar 1 of sequence type 32. J Bacteriol 2012, 194(24):6932.
53. Ke Y, Yuan X, Zhen Q, Wang Y, Li T, Sun Y, Song H, Huang L, Wang D, Cui B, Mao K, Chen Z*: Genome sequence of Brucella melitensis S66, an isolate of sequence type 8, prevalent in China. J Bacteriol 2012, 194(19):5451.
54. Ke Y, Yuan X, Wang Y, Bai Y, Xu J, Song H, Huang L, Chen Z*: Genome sequences of Brucella melitensis 16M and its two derivatives 16M1w and 16M13w, which evolved in vivo. J Bacteriol 2012, 194(19):5489.
55. Ke Y, Wang Y, Yuan X, Zhong Z, Qu Q, Zhou D, Zeng X, Xu J, Wang Z, Du X, Wang T, Yang R, Zhen Q, Yu Y, Huang L, Chen Z*: Altered Transcriptome of the B. melitensis Vaccine Candidate 16M_vjbR, Implications for Development of Genetically Marked Live Vaccine. Indian Journal of Microbiology 2012, 52(4):575-580.
56. Ke Y, Wang Y, Yuan X, Xu J, Zhen Q, Wang Z, Li T, Wang D, Huang L, Song H, Chen Z*: Complete genome sequence of Brucella suis field strain BCB025 of sequence type ST22. J Bacteriol 2012, 194(24):6959.
57. Gao G, Li J, Li T, Zhang Z, Wang L, Yuan X, Wang Y, Xu J, Ke Y, Huang L, Wang D, Chen Z*#, Xu X*#: Complete genome sequence of Brucella canis strain 118, a strain isolated from canine. J Bacteriol 2012, 194(23):6680.
2011年
58. Fu S, Xu J, Li X, Xie Y, Qiu Y, Du X, Yu S, Bai Y, Chen Y, Wang T, Wang Z, Yu Y, Peng G, Huang K, Huang L, Wang Y, Chen Z*: Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection. PLoS One 2012, 7(2):e29552.
59. Chen Y, Zhen Q, Wang Y, Xu J, Sun Y, Li T, Gao L, Guo F, Wang D, Yuan X, Yuan J, Huang L, Chen Z*#, Yu Y*#.Development of an extended multilocus sequence typing for genotyping of Brucella isolates.J Microbiol Methods. 2011 Aug;86(2):252-4.
60. Wang Y, Bai Y, Qu Q, Xu J, Chen Y, Zhong Z, Qiu Y, Wang T, Du X, Wang Z, Yu S, Fu S, Yuan J, Zhen Q, Yu Y, Chen Z*#, Huang L*#.The 16MΔvjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection. Vet Microbiol. 2011 Aug 5;151(3-4):354-62.
61. Chen Z, Qlu S, Wang Y, Wang Y, Liu S, Wang Z, Du X, Wang L, Guo J, Wang Z, Liu N, Yuan J, Song H, Huang L.Coexistence of blaNDM-1 with the prevalent blaOXA23 and blaIMP in pan-drug resistant Acinetobacter baumannii isolates in China.Clin Infect Dis. 2011 Mar 1;52(5):692-3.
【所獲榮譽】
獲授權專利5項
軟件著作權4項
新藥證書1項
診斷試劑CE證書3項
獲吉林省科技進步二等獎1項（第二）
中華預防醫學會科技進步二等獎1項（第五）
解放軍個人二等功1次、三等功1次
【聯系方式】
地址： 廣東省廣州市越秀區中山二路74号太阳集团1088vip
電話：020-87335382
E-mail：chenzliang5@mail.sysu.edu.cn
