學術簡曆
現任太阳集团1088vip副教授,博士生導師。2014年畢業于太阳集团app首页中山醫學院,獲微生物學博士學位,2015入職太阳集团1088vip,2020年受聘為副教授。主要研究方向為病毒感染與免疫分子機制、傳染病分子流行病學研究。主持國家自然科學基金項目3項,廣東省自然科學基金1項;作為課題骨幹參與“艾滋病和病毒性肝炎等重大傳染病防治”國家科技重大專項、教育部科學技術研究重大項目,及多項國家自然科學基金項目等研究工作。近五年來以第一作者/共同第一作者、獨立通訊/共同通訊作者分别在Proc Natl Acad Sci USA、Journal of Virology、Journal of Infectious Diseases、BMC Medicine、Journal of Infection、Cellular Microbiology、PLOS Neglected Tropical Diseases等雜志發表多篇論著。
社會兼職
中華醫學會微生物學與免疫學分會會員
主要承擔或參與的課題
1. 國家自然科學基金面上項目,寨卡病毒非結構蛋白介導突破胎盤屏障的分子機制研究,82171675,2022/01-2025/12,主持
2. 國家自然科學基金面上項目,細胞焦亡及其抑制劑在寨卡病毒誘發神經炎症及損傷的作用機制研究,81971146,2020/01-2023/12,主持
3. 廣東省自然科學基金面上項目,寨卡病毒誘發神經細胞焦亡介導神經系統炎症及損傷的機制研究,2019A1515010937,2019/10-2022/09,主持
4. 廣州市科技計劃項目,登革病毒血清I型新基因型入侵、遺傳變異與暴發流行的關聯研究,201804010121,2018/04-2021/03,子課題負責人
5. 國家自然科學基金青年項目,登革病毒蛋白NS4A參與天然免疫逃逸的功能和分子機制研究,81501744,2016/01-2018/12,主持
6. 國家科技重大專項項目,廣東省傳染病病原譜流行規律研究,2017ZX10103011,2017/01-2020/12,參與
7. 廣東省科技計劃項目,南海微生物來源的創新靶向藥物研究,GDME-20181004,2018/05-2020/05,參與
近期發表的主要文章
1. He Z, An S, Chen J, Zhang S, Tan C, Yu J, Ye H, Wu Y, et al. Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target. Proc Natl Acad Sci USA. 2020 Sep 22;117(38):23869-23878.
2. Yuan J, Yu J, Huang Y, He Z, Luo J, Wu Y, Zheng Y, Wu J, et al. Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus. BMC Med. 2020 Jul 31;18(1):204. doi: 10.1186/s12916-020-01663-1.
3. He Z. What Further Should Be Done to Control COVID-19 Outbreaks in Addition to Cases Isolation and Contact Tracing Measures? BMC Medicine. 2020 Mar 13;18(1):80. doi: 10.1186/s12916-020-01551-8.
4. He Z, Chen J, Zhu X, An S, Wu J, Li M. Reply to Hueston et al. Journal of Infectious Diseases. 2019, 220(9): 1540–1542.
5. Hu Y#, Dong X#, He Z#, Wu Y, Zhang S, Lin J, Yang Y, Chen J, An S, Yin Y, et al. Zika virus antagonizes interferon response in patients and disrupts RIG-I-MAVS interaction through its CARD-TM domains. Cell & Bioscience. 2019, 9:46.
6. Liu RF, He ZJ, Mei P, Xi JC, Cao XD, Yuan LH, Lu JH. Risk assessment and genomic characterization of Zika virus in China and its surrounding areas. Chinese Medical Journal. 2019;132(14): 1645-1653.
7. Zhu T, An S, Choy MT, Zhou J, Wu S, Liu S, Liu B, Yao Z, Zhu X, Wu J*, He Z*. LncRNA DUXAP9-206 directly binds with Cbl-b to augment EGFR signaling and promotes non-small cell lung cancer progression. Journal of Cellular and Molecular Medicine. 2019 Mar;23(3):1852-1864.
8. He Z, Chen J, Zhu X, An S, Dong X, Yu J, Zhang S, et al. NLRP3 Inflammasome Activation Mediates Zika Virus-Associated Inflammation. Journal of Infectious Diseases. 2018 May 25;217(12):1942-1951.
9. He Z, Zhu X, Wen W, Yuan J, Hu Y, Chen J, An S, et al. Dengue virus subverts host innate immunity by targeting adaptor protein MAVS. Journal of Virology. 2016 Jul 27;90(16):7219-7230.
10. Wen W#, He Z#, Jing Q, Hu Y, Lin C, Zhou R, Wang X, Su Y, Yuan J, et al. Cellular microRNA-miR-548g-3p modulates the replication of dengue virus. Journal of Infection. 2015 Jun;70(6):631-640.
11. Zhu X#, He Z#, Yuan J, Wen W, Huang X, Hu Y, Lin C, Pan J, Li R, et al. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cellular Microbiology. 2015 Jan;17(1):105-118.
12. Zhu X#, He Z#, Hu Y, Wen W, Lin C, Yu J, Pan J, Li R, Deng H, et al. MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB–dependent IFN production. PLOS Neglected Tropical Diseases. 2014 Aug 14;8(8):e3088.
13. Zhang D#, He Z#, Xu L, Zhu X, Wu J, Wen W, Zheng Y, Deng Y, Chen J, et al. Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China. International Journal of Infectious Diseases. 2014 Aug; 25:159-164.
招生專業
流行病學、公共衛生碩士(MPH)