ACADEMIC APPOINMENTS
Sun Yat-sen University, P.R.China March 2013-present
Department of Nutrition
Professor
Weill Cornell Medical College, USA December 2011-March 2013
Department of Pharmacology
Instructor
Mount Sinai School of Medicine, USA July 2010-November 2011
Department of Pharmacology and Systemic Therapeutics
Instructor
Mount Sinai School of Medicine, USA January 2010-July 2010
Department of Pharmacology and Systemic Therapeutics
Post-doctoral research fellow
Cleveland Clinic Foundation, USA August 2006 – January 2010
Department of Cell Biology, Lerner Research Institute
Post-doctoral research fellow
Case Western Reserve University, USA June 2002 - August 2006
Department of Nutrition，School of Medicine
Research assistant
Sun Yat-sen University of Medical Sciences, P.R.China. July 2000 - June 2002
Department of Preventive Medicine
Research faculty
Sun Yat-sen University of Medical Sciences, P.R.China. September 1997 - July 2000
Department of Nutrition
Research assistant
EDUCATIONS
Post-doctoral research fellow January 2010-July 2010
Mount Sinai School of Medicine, New York, NY
Department of Pharmacology and Systemic Therapeutics
Mentor: Dr. Arthur Cederbaum, Ph.D.
Post-doctoral research fellow August 2006 – January 2010
Cleveland Clinic Foundation, Cleveland, Ohio
Department of Cell Biology, Lerner Research Institute
Mentor: Dr. Thomas McIntyre, Ph.D.
Ph.D 2006
Case Western Reserve University, Cleveland, Ohio
Department of Nutrition, School of Medicine
Advisor: Dr. Henri Brunengraber, M.D., Ph.D.
M.S. 2000
Sun Yat-sen University of Medical Sciences, Guangzhou, China.
M.D. 1997
Harbin Medical University, Harbin, China.
AWARDS AND HORNORS
Medical Award of United Laboratories, Sun Yat-sen University of Medical Sciences, 1999
Excerllent Student Scholarship, Harbin Medical University, 1996
Outstanding student award, Harbin Medical University, 1994
OTHER PROFESSIONAL AFFILIATIONS
Member of Society of Free Radical Biology & Medicine
Member of Society of Mass Spectrometry
PUBLICATIONS (* corresponding author)
1. Yang, L*., Rozenfeld R., Wu, D., Devi, LA., Zhang, Z.*, and Cederbaum A*. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radical Biology & Medicine. 68: 260-267, 2014.
2. Ismailoglu, I., Chen, Q., Popowski, M., Yang, L., Gross, S.S. *, and Brivanlou, AH*. Huntingtin protein is essential for mitochondrial metabolism bioenergetics and structure in murine embryonic stem cells. Developmental Biology. 2014; 391: 230-240.
3. Wang, X., Wu D., Yang, L., Gan, L., Cederbaum, AI*. CYP2E1 Potentiates Ethanol-induction of Hypoxia and HIF-1α in vivo. Free Radical Biology & Medicine. 63:175-186, 2013.
4. Yang, L.*, Wu, D., Wang, X., and Cederbaum, AI*. Interactions between CYP2E1, JNK, Autophagy and oxidative stress in acute alcohol-induced fatty liver. Free Radical Biology & Medicine. 53; 1170-1180, 2012.
5. Wu, D., Wang, X., Yang, L., and Cederbaum, AI*. Role of Autophagy in the Modulation of Cytochrome P4502E1-mediated Binge Alcohol Liver Steatosis and Cytotoxicity. Free Radical Biology & Medicine. 53(6): 1346-57, 2012.
6. Cederbaum, AI*, Yang, L., Wang, X, Wu, D. CYP2E1 sensitizes the liver to LPS and TNF-induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen activated kiniases (review). International J of Hepatology. 2012; 2012: 582790.
7. Yang, L., Wu, D., and Cederbaum, AI*. CYP2E1, oxidative stress and MAPK signaling pathway in alcohol-induced hepatotoxicyt. (Review). J of Biochem and Pharm Res.2(2):74-90, 2014 .
8. Yang, L*., and Cederbaum, AI. Interaction of CYP2E1 and anti-oxidative stress factors in alcoholic liver disease (review). Recent Advances in Alcoholic Liver Disease, 27-45 ISBN: 978-81-7895-571-1, 2012.
9. Yang, L., Wu, D., Wand, X., and Cederbaum, AI*.. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1 induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radical Biology & Medicine. 2011; 51: 185-196.
10. Wang, X., Wu, D., Yang, L., Cederbaum, AI*. Hepatotoxicity mediated induced by TNFα was mediated by JNK1 but not JNK2. Hepatology. 2011. 54(5):1753-66.
11. Yang, L., and Cederbaum, AI*.. CYP2E1, oxidative stress and MAPK signaling pathway in alcoholic liver disease (review). Research Trends- Current Topics in Toxicology. 2011(7): 1-11.
12. Yang, L., Latchoumycandane, C, McMulllen, M.R., Pratt, B.T., Zhang, R., Papouchado, B.G., Nagy, L.E., Feldstein, A.E., and McIntyre TM*.. Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J. Biol. Chem. 2010; 285(29):22211-20.
13. Yang L., Kombu RS, Kasumov T, Zhu SH, Cendrouski AV, David F, Anderson VE, Kelleher JK, Brunengraber H*. Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: I. Interrelation between gluconeogenesis and catapleorosis: Formation of methoxamates from aminooxyacetate and ketoacids. J. Biol. Chem. 2008; 283(32): 21978-21987.
14. Yang L., Kasumov T, Kombu RS, Zhu SH, Cendrouski AV, David F, Anderson VE, Kelleher JK, Brunengraber H*. Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern. J. Biol. Chem. 2008; 283(32): 21988-21996.
15. Chen R., Yang L., and McIntyre TM*. Cytotoxic phospholipid oxidation products: cell death from mitochondrial damage and the intrinsic caspase cascade. J. Biol. Chem. 2007; 282(34):24842-50.
16. Chen J., Yang L., Foulks JM, Weyrich AS, Marathe GK, McIntyre TM*. Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. J Lipid Res. 2007; 48(11):2365-76.
17. Yang L., Kasumov T, Lynn Yu, Jobbins KA, David F, Kelleher JK, Previs SF, Joanne, K. Kelleher and Brunengraber H*. Metabolomic assays of the concentration and mass isotopomer distributions of gluconeogenic and citric acid cycle intermediates. Metabolomics. 2006; 2(2): 85-94
18. Yang L., Ling WH*, Ma J., Tang Z., Wu C.. Effect of lysophosphatidylcholine on cholesterol efflux from macrophage foam cells. Chinese Journal of Pathophysiology. 2001; 18 (1): 28-31.
19. Yang L., Ling WH*, Ma J., Tang Z.. Effect of calcium signaling pathway on cholesterol efflux promoted by lysophosphatidylcholine from macrophage foam cells. Chinese Journal of Arteriosclerosis. 2001; 9 (3): 190-193.
20. Yang L., Ling WH*. Oxidized low density lipoprotein and atherosclerosis (review). Foreign medical sciences (review). 2000; 27 (2): 58-61.
21. Wang S., Yang, L*. Mechanisms and research progresses of alcoholic fatty liver. International Liver Disease (review). 2013; 10-12-13.
CONFERENCE PRESENTATIONS
1. Yang L, Cederbaum, AI.. Thioredoxin is essential for CYP2E1 induced oxidative stress in HepG2 cells. The 2010 annual meeting of Society of Free Radical Biology and Medicine.
2. Latchoumycandane, C., Yang, L., Marathe, G., and McIntyre, TM. Oxidized phospholipids have a crucial role in TNFα-induced cell death. The 2010 annual meeting of Society of Free Radical Biology and Medicine.
3. Wang, X, Wu, D, Yang, L. Hepatotoxicity induced by CYP2E1 and TNFα was mediated by JNK1 but not JNK2. Annual Alcohol Meeting in Europe. Dec. 2010. Athence, Greece.
4. Yang L, Nagy L, McIntyre TM. Oxidative stress induced by ethanol in extra-hepatic organs. The 2009 annual meeting of Society of Free Radical Biology and Medicine. November 2009, San Francisco, CA.
5. Yang, L., Chen, R., Chen, X., Nagy, L.E., Salomon, R.G., and McIntyre, T.M. Chronic Ethanol Ingestion Increases Circulating Oxidized Phospholipids that are Potent Mitotoxic Agents. The 2007 annual meeting of Society of Free Radical Biology and Medicine, Novemer 2007, San Francisco, CA.
6. Rajan Kombu Subramanian, Takhar Kasumov, Lili Yang, Andrea Cendrowski, France David, Paul E. Minkler, Charles L. Hoppel, Vernon A. Anderson and Henri Brunengraber. Reassessment of the mechanisms by which aminooxyacetate (AOA) inhibits gluconeogenesis (GNG) from lactate. The FASEB Journal. 2007;21:804.1.
7. Yang L, Kasumov T, Jobbins KA, Thomas KR, David F, Kelleher JK, Previs SF, and Brunengraber H. Assay of the concentration and P13PC-isotopic enrichment of gluconeogenic and citric acid cycle intermediates by gas chromatography-mass spectrometry. FASEB J. 2006 20:A1466.
8. Yang L, Kasumov T, Zhu SH, Jobbins KA, Thomas KR, Adams J, David F, and Brunengraber H. Metabolomic study of the labeling of liver gluconeogenesis (GNG) and citric acid cycle (CAC) with NaHP13PCOB3B and [1,4-P13PCB2B]succinate. FASEB J. 2006 20:A1269-A1270.
9. Bian F, Kasumov K, Yang LL, Jobbins KA, Isquick SF, Minkler PE, Anderson VE, Hoppel CL, Brunengraber H. Hepatic metabolism of the dicarboxylate azelate production of malonyl-CoA and of anaplerotic methylmalonyl-CoA. FASEB J. 2006 20:A138.
10. Bian F, Yang L, Kasumov T, Minkler PE, Anderson VE, Hoppel CH, and Brunengraber H. Pathway discovery via the association of metabolomicsand mass isotopomer analysis. 3rd nternational Conference on Pathways, Networks, and Systems: Theory and Experiments. October 2005. Rhodes, Greece.
11. Yang L, Bian F, Kasumov T, Minkler PE, Anderson VE, Hoppel CL, Brunengraber H. Pathway discovery via the association of metabolomics and mass isotopomer analysis. First Scientific Meeting of the Metabolomics Society. June 2005. Tsuruoka City, Japan.
12. Yang L, Kasumov T, Thomas KR, Jobbins KA, Adams J, David F, and Brunengraber H. In support of a non-phosphoenolpyruvate (PEP)-mediated gluconeogenesis from lactate in rat liver. The 2004 Annual Meeting of Experimental Biology. April 2004, Washington DC.
13. Yang L, and Ling WH. Effect of lysophosphatidylcholine on cholesterol efflux and its mechanisms. Symposium of Chinese Association of pathophysiology. 2001. Shanghai, P.R.China.
