Brief Introduction
Dr. Chen is a professor in Nutritional Epidemiology at the Dept. of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University (SYSU).
Dr. Chen received his M.D. degree (1988) from Hunan (Xiangya) Medical University and M.S. degress (1991) from Tongji Medical University and Ph.D. degrees (2003) from the Chinese University of Hong Kong (CUHK). Since 1991, he had worked as a Teaching Assitant and a Lecturer at the Dept. of Nutrition and Food Hygiene of Sun Yat-sen University of Medical Science, and have been working as an Associate Professor (1994-2008) and a Professor (2008-) at the current department. During 1999-2004, he was a PhD candidate, Research Associate and Post-Doctoral Fellow at the School of Public Health of CUHK.
Dr. Chen has received a few prestigious awards, including four grants of National Natural Science Foundation of China (NSFC), a Program for New Century Excellent Talents in University (Ministry of Education), and several grants from the Chinese Nutrition Society, and company-funded fundations. He has published 100 articles in peer-reviewed international journals, with 1370 citations; and more than 50 articles in domestic journals.
Dr. Chen also served as the board member of the council of Chinese Nutrition Society; the Vice director of the council of Guangdong Nutrition Society, etc.
Research
Research Interests: the risk factors in nutritional aspects for osteoporosis, atherosclerosis, MetS, fatty liver, and body composition.
Important study: Guangzhou residents’ Health Study; Participants: about 4000 Chinese adults aged 35-75 years; Design: prospective study, cohort established during 200-2010, and followed-up every 3 years; main exposures: dietary and nutritional factors, gut flora,etc.; Main endpoints: DXA-BMD, IMTs, NAFLD, MetS, body composition; Samples collected: blood, urine and feces.
Grant Awards
1. PI: Associations of Fatty acids in diet, plasma and RBC wth atherosclerosis in middle-aged and elderly adults: a 6-y propective study. National Natural Science Foundation of China (NSFC). No. 81472965, 2015-2018.
2. PI: Effects of dietary pattern, inflammation cytokines, oxidative stress and their related candidate genes on osteoporosis in middle aged adults in Guangzhou, China: a 6-year follow up study. NSFC, NO. 81273049, 2013-2016.
3. Co_I (1st): Effect of nutritional and dietary factors and gene polymorphism on atherosclerosis: A longitudinal study. the key program of NSFC, No. 81130052, 2012-2016.
4. PI, Interaction effects of dietary antioxidants, antioxidantive enzymes, oxdative stress, and candidate genes on risk of hip fracture in women. NSFC, No. 81072299. 2011-2013
5. PI,Interaction effects of candidate genes and dietary pattern on hip fracture in women. NSFC, No. 30872100. 2009-2011.
6. Co-PI, Calcium and milk supplementation on bone mass and calcium metabolism in 800 children, lactation women and postmenopausal women: 2-y double-blinded randomized controlled trial. Sub-study, Funded by National Key Project of Scientific and Technical Supporting Programs, the Ministry of Science & Technology of China (NO. 2008BAI58B02), 2009~2011.
7. PI, Effects of dietary and gene polymorphism on glucose metabolism in obesity children and adolescents. Program for New Century Excellent Talents in University (NCET), Ministry of Education, PR China, 2006. NCET-06-0719, 2007-2009.
8. PI, A longitudinal study on the epidemiological trend and risk factors of cardio-metabolic disorders and osteoporosis in middle-aged and elderly adults in Guangzhou. No.2007032, 2007-2016.
Selected Publication
(*: corresponding author)
1. Cao Y, Wang C, Liu J, Liu ZM, Ling WH, Chen YM*. Greater serum carotenoid levels associated with lower prevalence of nonalcoholic fatty liver disease in Chinese adults. Sci Rep 2015 Jul, 5,12951; doi: 10.1038/srep12951.
2. Chen GD, Zhu YY, Cao Y, Liu J, Shi WQ, Liu ZM, Chen YM*. Association of dietary consumption and serum levels of vitamin A and β-carotene with bone mineral density in Chinese adults. Bone. 2015; 79: 110–115.
3. Dai XW, Chen YM*, Zeng FF, Sun LL, Chen CG, Su YX*. Association between n-3 polyunsaturated fatty acids in erythrocytes and metabolic syndrome in Chinese men and women. Eur J Nutr 2015 May 3. [Epub ahead of print], DOI: 10.1007/s00394-015-0912-3
4. Lu MS, Fang YJ, Pan ZZ, Zhong X, Zheng MC, Chen YM*, Zhang CX*. Choline and Betaine Intake and Colorectal Cancer Risk in Chinese Population: A Case-Control Study. PLoS One. 2015 Mar 18;10(3):e0118661.
5. Cao Y, Wang C, Guan K, Xu Y, Su YX*, Chen YM*. Association of magnesium in serum and urine with carotid intima-media thickness and serum lipids in middle-aged and elderly Chinese: a community-based cross-sectional study. Eur J Nutr 2015 Mar 7. [Epub ahead of print]. DOI: 10.1007/s00394-015-0839-8
6. Chen YM, Liu Y, Liu YH, Wang X, Guan K, Zhu HL*. Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults. Int J obes 2015 Mar;39(3):465-71.
7. Ye YB, Chen AL, Lu W, Zhuo SY, Liu J, Guan JH, Deng WP, Fang S, Li YB*, Chen YM*. Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial. Mol Nutr Food Res 2015 Feb;59(2):240-9.
8. Liu J#,, Shi WQ#,, Cao Y, He LP, Guan K, Ling WH, Chen YM*. Higher serum carotenoid concentrations associated with a lower prevalence of the metabolic syndrome in middle-aged and elderly Chinese adults. Br J Nutr 2014 Dec;112(12):2041–2048.
9. Sun LL#,, Li BL#,, Xie HL, Fan F, Yu WZ, Wu BH, Xue WQ, Chen YM*. Dietary intake of antioxidative nutrients and risk of hip fracture in elderly Chinese: a case-control study. Br J Nutr 2014 Oct, 112(10): 1706–1714.
10. Zhang ZQ, He LP, Liu YH, Guan K, Su YX*, Chen YM*. Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men. Osteoporos Int 2014 Oct;25(10):2417-25.
11. Liu J, Sun LL, He LP, Ling WH, Liu ZM, Chen YM*. Associations of soy food consumption with cardiometabolic disturbances and carotid intima-media thickness in Chinese adults.. Nutr Metab Cardiovasc Dis 2014 Oct;24(10):1097-104.
12. Zhang ZQ, Liu YH, Xu Y, Dai XW, Ling WH, Su YX*, Chen YM*. The validity of the body adiposity index in predicting percentage body fat and cardiovascular risk factors among Chinese. Clin Endocrinol 2014 Sep;81(3):356-62.
13. Zeng FF, Xie HL, Fan F, Cao WT, Xue WQ, Wu BH, Zhu HL, Chen YM*. Diet-quality scores and risk of hip fractures in elderly urban Chinese in Guangdong, China: a case-control study. Geriatr Gerontol Int 2014 Aug;25(8):2131-41.
14. Zeng FF, Sun LL, Liu YH, Xu Y, Guan K, Ling WH, Chen YM*. Higher Erythrocyte n–3 PUFAs Are Associated with Decreased Blood Pressure in Middle-Aged and Elderly Chinese Adults. J Nutr 2014 Aug;144(8):1240-6.
15. Zhang ZQ, He LP, Xie XY, Ling WH, Deng J, Su YX*, Chen YM*. Association of simple anthropometric indices and body fat with early atherosclerosis in Chinese adults. PLoS ONE 2014 Aug 4;9(8):e104361.
16. Zeng FF, Xue WQ, Cao WT, Wu BH, Xie HL, Fan F, Zhu HL*, Chen YM*. Diet-quality scores and risk of hip fractures in elderly urban Chinese in Guangdong, China: a case–control study. Osteoporos Int 2014 Aug;25(8):2131-41.
17. Wang CY, Chen ZW, Zang T, Liu J, Chen SH, Liu SH, Han LY, Hui ZH, Chen YM*. Elevated Plasma Homocysteine Level is Associated with Ischemic Stroke in Chinese Essential Hypertensive Patients. Eur J Intern Med 2014 Jul;25(6):538-44.
18. Zhang ZQ, Ma XM, Huang ZW, Yang XG, Chen YM*, Su YX*. Effects of milk salt supplementation on bone mineral gain in pubertal Chinese adolescents: A 2-year randomized, double-blind, controlled, dose–response trial. Bone 2014 May; 65: 69–76.
19. Xu Y, Zeng FF, He LP, Ling WH, Chen WQ, Chen YM*. Comparison of predictive value of cardiometabolic indices for subclinical atherosclerosis in Chinese adults. PLoS ONE 2014 Apr 1;9(4):e93538.
20. Zeng FF, Xu CH, Liu YT, Fan YY, Lin XL, Lu YK, Zhang CX, Chen YM*. Choline and betaine intakes are associated with reduced risk of nasopharyngeal carcinoma in adults: a case-control study. Br J Cancer 2014 Feb 4;110(3):808-16.
21. Zhang ZQ, Ho SC, Chen ZQ, Zhang CX, Chen YM*. Reference values of bone mineral density and prevalence of osteoporosis in Chinese adults. Osteoporos Int 2014 Feb;25(2):497-507
22. Dai XW, Zhang B, Wang P, Chen CG, Chen YM*, Su YX*. Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. Atherosclerosis 2014 Jan;232(1):79-85.
23. Xie HL, Wu BH, Xue WQ, He MG, Fan F, Ouyang WF, Tu SL, Zhu HL*, Chen YM*. Greater intake of fruit and vegetables is associated with lower risk of osteoporosis-related hip fractures in elderly Chinese: a 1:1 matched case-control study. Osteoporos Int 2013 Nov;24(11):2827-36
24. Liu J, Zeng FF, Liu ZM, Zhang CX, Ling WH, Chen YM*. Effect of blood triglyceride on cardiovascular and all-cause mortality: A systematic review and meta-analysis of 61 prospective studies. Lipids Health Dis 2013 October 29; 2013, 12:159.
25. Liu YT, Fan YY, Xu CH, Lin XL, Lu YK, Zhang XL, Zhang CX, Chen YM*. Habitual consumption of soy products and risk of nasopharyngeal carcinoma in Chinese adults: a case-control study. PLoS ONE 2013 October;8(10):e77822.
26. Zeng FF, Fan F, Xue WQ, Xie HL, Wu BH, Tu SL, Ouyang WF, Chen YM*. The association of red meat, poultry, and egg consumption with risk of hip fractures in elderly Chinese: a case-control study. Bone 2013 October; 56(2):242–248.
27. Zhang ZQ, Deng J, He LP, Ling WH, Su YX*, Chen YM*. Comparison of various anthropometric and body fat indices in identifying cardiometabolic disturbances in Chinese men and women. PLoS ONE 2013 Aug 12;8(8):e70893.
28. Zeng FF, Wu BH, Fan F, Xie HL, Xue WQ, Zhu HL*, Chen YM*. Dietary patterns and the risk of hip fractures in elderly Chinese: A matched case-control study. J Clin Endocrinol Metab 2013 Jun;98(6):2347-55. doi: 10.1210/jc.2013-1190.
29. Liu YH , Xu Y, Wen YB, Guan K, Ling WH, He LP, Su YX*, Chen YM*. Association of weight-adjusted body fat and fat distribution with bone mineral density in middle-aged Chinese adults: A cross-sectional study. PLoS ONE 2013 May 20;8(5):e63339.
30. Fan F, Xue WQ, Wu BH, He MG, Xie HL, Ouyang WF, Tu SL, Chen YM*. Higher fish intake is associated with a lower risk of hip fractures in Chinese nen and women: A matched case-control study. PLoS ONE 2013;8(2): e56849.
31. Li JJ, Huang ZW, Wang RQ, Ma XM, Zhang ZQ, Liu Z, Chen YM*, Su YX* Fruit and vegetable intake and bone mass in Chinese adolescents, young and postmenopausal women. Public Health Nutr. 2013 Jan;16(1):78-86.
32. Zhang CX, Chen YM*, Chen WQ, Su YX, Wang CL, Wu JN. Food group intake among adolescents in Guangzhou city compared with the Chinese dietary guidelines. Asia Pac J Clin Nutr 2012;21(3):450-6.
33. Wang P, Chen YM*, He LP, Chen CG, Zhang B, Xue WQ, Su YX*. Association of natural intake of dietary plant sterols with carotid intima–media thickness and blood lipids in Chinese adults: a cross-section study. PLoS ONE. 2012; 7(3): e32736.
34. Liu YT, Dai JJ, Xu CH, Lu YK, Fan YY, Zhang XL, Zhang CX, Chen YM*. Greater intake of fruit and vegetables is associated with lower risk of nasopharyngeal carcinoma in Chinese adults: a case-control study. Cancer Causes Control. 2012 Apr;23(4):589-99.
35. Ye YB, Wang ZL, Zhuo SY, Lu W, Liao HF, Verbruggen MA, Fang S, Mai HY, Chen YM*, Su YX*. Soy germ isoflavones improve menopausal symptoms but have no effect on blood lipids in early postmenopausal Chinese women: a randomized placebo-controlled trial. Menopause. 2012 Jul;19(7):791-798.
36. Liu Z, Qiu L, Chen YM *, Su YX *. Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail. Arch Gynecol Obstet. 2011 Feb;283(2):205-11.
37. He LP, Tang XY, Ling WH, Chen WQ, Chen YM*. Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies. Heart. 2010;96:339-346.
38. Chen YM, Ho SC*, Lam SS. Higher sea fish intake is associated greater bone mass and lower osteoporosis risk in postmenopausal Chinese women. Osteoporos Int. 2010 Jun;21(6):939-46
39. Liu J, Ho SC, Su YX, Chen WQ, Zhang CX, Chen YM*. Effect of long-term intervention of soy isoflavones on bone mineral density in women: A meta-analysis of randomized controlled trials. Bone 2009 May;44(5):948-53.
40. Wu JN, Ho SC, Zhou C, Ling WH, Chen WQ, Wang CL, Chen YM*. Coffee consumption and risk of coronary heart diseases: A meta-analysis of 21 prospective cohort studies. Int J Cardiol. 2009; 137: 216-225.
41. Li X, He GP, Zhang B, Chen YM*, Su YX*. Interactions of interleukin-6 gene polymorphisms with calcium intake and physical activity on bone mass in Chinese pre-menarche girls. Osteoporos Int 2008 Nov;19(11):1629-37.
42. Zhang B, Chen YM*, Huang LL, Zhou XX, Chen CG, Ye YB, Su YX*. Greater habitual soyfood consumption is associated with decreased carotid intima-media thickness and better plasma lipids in Chinese middle-aged adults. Atherosclerosis 2008 June; 198(2): 403-411.
43. Wang CL, Tang XY, Chen WQ, Su YX, Zhang CX, Chen YM*. Association of Estrogen Receptor Gene Polymorphisms with Bone Mineral Density in Chinese Women: A Meta-Analysis. Osteoporos Int 2007;18(3):295-305
44. Chen YM, Teucher B, Tang XY, Dainty JR, Lee KK, Woo JL, Ho SC*. Calcium Absorption in Postmenopausal Chinese Women: A Randomized Crossover Intervention Study. Br J Nutr 2007;97(1):160-6.
45. Chen YM, Ho SC*, Woo JLF. Greater fruit and vegetable intake is associated with increased bone mass among postmenopausal Chinese women. Br J Nutr 2006; 96(4):745-51
46. Chen YM, Ho SC*, Lam SS, Chan SS. Validity of body mass index and waist circumference in the classification of obesity as compared to percent body fat in Chinese middle-aged women. Int J Obes 2006; 30(6): 918-925.
47. Chen YM, Ho SC*. Lam SSH, Ho SSS, Woo JLF. Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Menopause 2004; 11(3): 246-254.
48. Chen YM, Ho SC*, Lam SS, Ho SS, Woo JL. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab. 2003 Oct; 88(10):4740-4747.